1xb4

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{{Seed}}
 
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[[Image:1xb4.png|left|200px]]
 
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==Crystal structure of subunit VPS25 of the endosomal trafficking complex ESCRT-II==
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The line below this paragraph, containing "STRUCTURE_1xb4", creates the "Structure Box" on the page.
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<StructureSection load='1xb4' size='340' side='right'caption='[[1xb4]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1xb4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XB4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XB4 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xb4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xb4 OCA], [https://pdbe.org/1xb4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xb4 RCSB], [https://www.ebi.ac.uk/pdbsum/1xb4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xb4 ProSAT]</span></td></tr>
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{{STRUCTURE_1xb4| PDB=1xb4 | SCENE= }}
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</table>
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== Function ==
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===Crystal structure of subunit VPS25 of the endosomal trafficking complex ESCRT-II===
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[https://www.uniprot.org/uniprot/VPS25_YEAST VPS25_YEAST] Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex.<ref>PMID:12194858</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 15579210 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xb/1xb4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_15579210}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xb4 ConSurf].
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1XB4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XB4 OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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Crystal structure of subunit VPS25 of the endosomal trafficking complex ESCRT-II., Wernimont AK, Weissenhorn W, BMC Struct Biol. 2004 Dec 4;4(1):10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15579210 15579210]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Single protein]]
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[[Category: Weissenhorn W]]
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[[Category: Weissenhorn, W.]]
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[[Category: Wernimont AK]]
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[[Category: Wernimont, A K.]]
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[[Category: Winged helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:19:51 2008''
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Current revision

Crystal structure of subunit VPS25 of the endosomal trafficking complex ESCRT-II

PDB ID 1xb4

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