1nbq

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:47, 10 April 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1nbq.png|left|200px]]
 
-
<!--
+
==Crystal Structure of Human Junctional Adhesion Molecule Type 1==
-
The line below this paragraph, containing "STRUCTURE_1nbq", creates the "Structure Box" on the page.
+
<StructureSection load='1nbq' size='340' side='right'caption='[[1nbq]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1nbq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NBQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NBQ FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nbq OCA], [https://pdbe.org/1nbq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nbq RCSB], [https://www.ebi.ac.uk/pdbsum/1nbq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nbq ProSAT]</span></td></tr>
-
{{STRUCTURE_1nbq| PDB=1nbq | SCENE= }}
+
</table>
-
 
+
== Function ==
-
===Crystal Structure of Human Junctional Adhesion Molecule Type 1===
+
[https://www.uniprot.org/uniprot/JAM1_HUMAN JAM1_HUMAN] Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus.
-
 
+
== Evolutionary Conservation ==
-
 
+
[[Image:Consurf_key_small.gif|200px|right]]
-
<!--
+
Check<jmol>
-
The line below this paragraph, {{ABSTRACT_PUBMED_12697893}}, adds the Publication Abstract to the page
+
<jmolCheckbox>
-
(as it appears on PubMed at http://www.pubmed.gov), where 12697893 is the PubMed ID number.
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nb/1nbq_consurf.spt"</scriptWhenChecked>
-
-->
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
{{ABSTRACT_PUBMED_12697893}}
+
<text>to colour the structure by Evolutionary Conservation</text>
-
 
+
</jmolCheckbox>
-
==About this Structure==
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nbq ConSurf].
-
1NBQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NBQ OCA].
+
<div style="clear:both"></div>
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
Crystal structure of human junctional adhesion molecule 1: implications for reovirus binding., Prota AE, Campbell JA, Schelling P, Forrest JC, Watson MJ, Peters TR, Aurrand-Lions M, Imhof BA, Dermody TS, Stehle T, Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5366-71. Epub 2003 Apr 15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12697893 12697893]
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Aurrand-Lions, M.]]
+
[[Category: Aurrand-Lions M]]
-
[[Category: Campbell, J A.]]
+
[[Category: Campbell JA]]
-
[[Category: Dermody, T S.]]
+
[[Category: Dermody TS]]
-
[[Category: Forrest, J C.]]
+
[[Category: Forrest JC]]
-
[[Category: Imhof, B A.]]
+
[[Category: Imhof BA]]
-
[[Category: Peters, T R.]]
+
[[Category: Peters TR]]
-
[[Category: Prota, A E.]]
+
[[Category: Prota AE]]
-
[[Category: Schelling, P.]]
+
[[Category: Schelling P]]
-
[[Category: Stehle, T.]]
+
[[Category: Stehle T]]
-
[[Category: Watson, M J.]]
+
[[Category: Watson MJ]]
-
[[Category: Adhesion molecule]]
+
-
[[Category: Immunoglobulin superfamily]]
+
-
[[Category: Reovirus receptor]]
+
-
[[Category: Tight junction formation]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:23:41 2008''
+

Current revision

Crystal Structure of Human Junctional Adhesion Molecule Type 1

PDB ID 1nbq

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1nbq"
Personal tools