1rji

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{{Seed}}
 
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[[Image:1rji.png|left|200px]]
 
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==Solution Structure of BmKX, a novel potassium channel blocker from the Chinese Scorpion Buthus martensi Karsch==
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The line below this paragraph, containing "STRUCTURE_1rji", creates the "Structure Box" on the page.
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<StructureSection load='1rji' size='340' side='right'caption='[[1rji]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1rji]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesobuthus_martensii Mesobuthus martensii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RJI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RJI FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 21 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rji OCA], [https://pdbe.org/1rji PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rji RCSB], [https://www.ebi.ac.uk/pdbsum/1rji PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rji ProSAT]</span></td></tr>
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{{STRUCTURE_1rji| PDB=1rji | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SCKI_MESMA SCKI_MESMA] Does not show any effect on Na(+), Ca(2+) currents, nor on voltage-gated and calcium-activated potassium channels.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Scorpion venom is a rich source of bioactive peptides. From the venom of Chinese scorpion Buthus martensi Karsch (BmK), a novel short chain peptide BmKX of 31-amino acid residues was purified, and its amino acid sequence and gene structure were determined. The gene of BmKX was composed of two exons interrupted by an 86-bp intron at the codon-7 upstream of the mature peptide. Although its gene structure is similar to those of other known scorpion toxins, its amino acid sequence, especially the cysteine framework, is different from those of all other known subfamilies of short-chain scorpion toxins. The solution structure of BmKX, determined with two-dimensional NMR spectroscopy, shows that BmKX also forms a typical cysteine-stabilized alpha/beta scaffold adopted by most short-chain scorpion toxins, consisting of a short 3(10)-helix and a two-stranded antiparallel beta-sheet, and the short N-terminal segment forms a pseudo-strand of the beta-sheet. However, the orientation between the helix and the beta-sheet is significantly different from the others, which might be the reason for its unique but still unclear physiological function.
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===Solution Structure of BmKX, a novel potassium channel blocker from the Chinese Scorpion Buthus martensi Karsch===
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A novel short-chain peptide BmKX from the Chinese scorpion Buthus martensi Karsch, sequencing, gene cloning and structure determination.,Wang CG, Cai Z, Lu W, Wu J, Xu Y, Shi Y, Chi CW Toxicon. 2005 Mar 1;45(3):309-19. Epub 2005 Jan 20. PMID:15683869<ref>PMID:15683869</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1rji" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_15683869}}, adds the Publication Abstract to the page
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*[[Potassium channel toxin 3D structures|Potassium channel toxin 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 15683869 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15683869}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1RJI is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RJI OCA].
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[[Category: Mesobuthus martensii]]
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[[Category: Cai Z]]
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==Reference==
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[[Category: Chi C-W]]
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A novel short-chain peptide BmKX from the Chinese scorpion Buthus martensi Karsch, sequencing, gene cloning and structure determination., Wang CG, Cai Z, Lu W, Wu J, Xu Y, Shi Y, Chi CW, Toxicon. 2005 Mar 1;45(3):309-19. Epub 2005 Jan 20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15683869 15683869]
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[[Category: Shi Y]]
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[[Category: Single protein]]
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[[Category: Wang C-G]]
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[[Category: Cai, Z.]]
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[[Category: Wu J]]
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[[Category: Chi, C W.]]
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[[Category: Xu Y]]
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[[Category: Shi, Y.]]
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[[Category: Wang, C G.]]
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[[Category: Wu, J.]]
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[[Category: Xu, Y.]]
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[[Category: 3-10 helix]]
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[[Category: Beta sheet]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:23:53 2008''
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Current revision

Solution Structure of BmKX, a novel potassium channel blocker from the Chinese Scorpion Buthus martensi Karsch

PDB ID 1rji

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