1qg2

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{{Seed}}
 
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[[Image:1qg2.png|left|200px]]
 
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==CANINE GDP-RAN R76E MUTANT==
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The line below this paragraph, containing "STRUCTURE_1qg2", creates the "Structure Box" on the page.
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<StructureSection load='1qg2' size='340' side='right'caption='[[1qg2]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1qg2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QG2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QG2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_1qg2| PDB=1qg2 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qg2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qg2 OCA], [https://pdbe.org/1qg2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qg2 RCSB], [https://www.ebi.ac.uk/pdbsum/1qg2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qg2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RAN_CANLF RAN_CANLF] GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2. Enhances AR-mediated transactivation.[UniProtKB:P62826]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qg/1qg2_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qg2 ConSurf].
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<div style="clear:both"></div>
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===CANINE GDP-RAN R76E MUTANT===
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==See Also==
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*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_10356329}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10356329 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10356329}}
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==About this Structure==
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1QG2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QG2 OCA].
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==Reference==
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Engineered mutants in the switch II loop of Ran define the contribution made by key residues to the interaction with nuclear transport factor 2 (NTF2) and the role of this interaction in nuclear protein import., Kent HM, Moore MS, Quimby BB, Baker AM, McCoy AJ, Murphy GA, Corbett AH, Stewart M, J Mol Biol. 1999 Jun 11;289(3):565-77. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10356329 10356329]
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[[Category: Canis lupus familiaris]]
[[Category: Canis lupus familiaris]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Baker, A M.E.]]
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[[Category: Baker AME]]
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[[Category: Corbett, A H.]]
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[[Category: Corbett AH]]
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[[Category: Kent, H M.]]
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[[Category: Kent HM]]
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[[Category: McCoy, A J.]]
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[[Category: McCoy AJ]]
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[[Category: Moore, M S.]]
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[[Category: Moore MS]]
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[[Category: Murphy, G A.]]
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[[Category: Murphy GA]]
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[[Category: Quimby, B B.]]
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[[Category: Quimby BB]]
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[[Category: Stewart, M.]]
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[[Category: Stewart M]]
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[[Category: Gtpase]]
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[[Category: Nuclear transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:37:39 2008''
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Current revision

CANINE GDP-RAN R76E MUTANT

PDB ID 1qg2

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