1z8u

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{{Seed}}
 
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[[Image:1z8u.png|left|200px]]
 
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==Crystal structure of oxidized alpha hemoglobin bound to AHSP==
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The line below this paragraph, containing "STRUCTURE_1z8u", creates the "Structure Box" on the page.
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<StructureSection load='1z8u' size='340' side='right'caption='[[1z8u]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1z8u]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z8U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z8U FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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{{STRUCTURE_1z8u| PDB=1z8u | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z8u OCA], [https://pdbe.org/1z8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z8u RCSB], [https://www.ebi.ac.uk/pdbsum/1z8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z8u ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AHSP_HUMAN AHSP_HUMAN] Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia.<ref>PMID:12066189</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z8/1z8u_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z8u ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of oxidized alpha hemoglobin bound to AHSP===
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==See Also==
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*[[Hemoglobin 3D structures|Hemoglobin 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_15931225}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 15931225 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_15931225}}
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==Disease==
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Known disease associated with this structure: Erythremias, alpha- OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141800 141800]], Heinz body anemias, alpha- OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141800 141800]], Methemoglobinemias, alpha- OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141800 141800]], Thalassemias, alpha- OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141800 141800]]
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==About this Structure==
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1Z8U is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z8U OCA].
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==Reference==
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Structure of oxidized alpha-haemoglobin bound to AHSP reveals a protective mechanism for haem., Feng L, Zhou S, Gu L, Gell DA, Mackay JP, Weiss MJ, Gow AJ, Shi Y, Nature. 2005 Jun 2;435(7042):697-701. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15931225 15931225]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Feng, L.]]
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[[Category: Feng L]]
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[[Category: Gell, D A.]]
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[[Category: Gell DA]]
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[[Category: Gow, A J.]]
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[[Category: Gow AJ]]
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[[Category: Gu, L.]]
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[[Category: Gu L]]
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[[Category: Mackay, J P.]]
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[[Category: Mackay JP]]
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[[Category: Shi, Y.]]
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[[Category: Shi Y]]
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[[Category: Weiss, M J.]]
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[[Category: Weiss MJ]]
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[[Category: Zhou, S.]]
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[[Category: Zhou S]]
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[[Category: Ahsp]]
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[[Category: Alpha haemoglobin]]
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[[Category: Interaction]]
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[[Category: Oxidation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:39:31 2008''
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Current revision

Crystal structure of oxidized alpha hemoglobin bound to AHSP

PDB ID 1z8u

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OCA

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