2gcj

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:27, 14 February 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2gcj.png|left|200px]]
 
-
<!--
+
==Crystal Structure of the Pob3 middle domain==
-
The line below this paragraph, containing "STRUCTURE_2gcj", creates the "Structure Box" on the page.
+
<StructureSection load='2gcj' size='340' side='right'caption='[[2gcj]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2gcj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GCJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GCJ FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gcj OCA], [https://pdbe.org/2gcj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gcj RCSB], [https://www.ebi.ac.uk/pdbsum/2gcj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gcj ProSAT]</span></td></tr>
-
{{STRUCTURE_2gcj| PDB=2gcj | SCENE= }}
+
</table>
-
 
+
== Function ==
-
===Crystal Structure of the Pob3 middle domain===
+
[https://www.uniprot.org/uniprot/POB3_YEAST POB3_YEAST] Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. Transcription elongation is promoted by the repression of transcription initiation from cryptic sites. Also acts in establishing transcription initiation complexes and promotes SPT15/TBP-binding to a TATA box. Together with replication factor-A protein (RPA), FACT may play a role in nucleosome deposition during DNA replication.<ref>PMID:10413469</ref> <ref>PMID:10924459</ref> <ref>PMID:11432837</ref> <ref>PMID:12524332</ref> <ref>PMID:14585989</ref> <ref>PMID:12934008</ref> <ref>PMID:15082784</ref> <ref>PMID:15987999</ref> <ref>PMID:16678108</ref>
-
 
+
== Evolutionary Conservation ==
-
 
+
[[Image:Consurf_key_small.gif|200px|right]]
-
<!--
+
Check<jmol>
-
The line below this paragraph, {{ABSTRACT_PUBMED_16678108}}, adds the Publication Abstract to the page
+
<jmolCheckbox>
-
(as it appears on PubMed at http://www.pubmed.gov), where 16678108 is the PubMed ID number.
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gc/2gcj_consurf.spt"</scriptWhenChecked>
-
-->
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
{{ABSTRACT_PUBMED_16678108}}
+
<text>to colour the structure by Evolutionary Conservation</text>
-
 
+
</jmolCheckbox>
-
==About this Structure==
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gcj ConSurf].
-
2GCJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GCJ OCA].
+
<div style="clear:both"></div>
-
 
+
== References ==
-
==Reference==
+
<references/>
-
The structure of the yFACT Pob3-M domain, its interaction with the DNA replication factor RPA, and a potential role in nucleosome deposition., VanDemark AP, Blanksma M, Ferris E, Heroux A, Hill CP, Formosa T, Mol Cell. 2006 May 5;22(3):363-74. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16678108 16678108]
+
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
-
[[Category: Single protein]]
+
[[Category: VanDemark AP]]
-
[[Category: VanDemark, A P.]]
+
-
[[Category: Chromatin]]
+
-
[[Category: Double ph domain]]
+
-
[[Category: Fact]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:41:09 2008''
+

Current revision

Crystal Structure of the Pob3 middle domain

PDB ID 2gcj

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2gcj"
Personal tools