1gjv

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(New page: 200px<br /> <applet load="1gjv" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gjv, resolution 2.70&Aring;" /> '''BRANCHED-CHAIN ALPH...)
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[[Image:1gjv.gif|left|200px]]<br />
 
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<applet load="1gjv" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1gjv, resolution 2.70&Aring;" />
 
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'''BRANCHED-CHAIN ALPHA-KETOACID DEHYDROGENASE KINASE (BCK) COMPLXED WITH ATP-GAMMA-S'''<br />
 
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==Overview==
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==Branched-chain alpha-ketoacid dehydrogenase kinase (BCK) complxed with ATP-gamma-S==
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Mitochondrial protein kinases (mPKs) are molecular switches that, down-regulate the oxidation of branched-chain alpha-ketoacids and, pyruvate. Elevated levels of these metabolites are implicated in disease, states such as insulin-resistant Type II diabetes, branched-chain, ketoaciduria, and primary lactic acidosis. We report a three-dimensional, structure of a member of the mPK family, rat branched-chain alpha-ketoacid, dehydrogenase kinase (BCK). BCK features a characteristic, nucleotide-binding domain and a four-helix bundle domain. These two, domains are reminiscent of modules found in protein histidine kinases, (PHKs), which are involved in two-component signal transduction systems., Unlike PHKs, BCK dimerizes through direct interaction of two opposing, nucleotide-binding domains. ... [[http://ispc.weizmann.ac.il/pmbin/getpm?11562470 (full description)]]
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<StructureSection load='1gjv' size='340' side='right'caption='[[1gjv]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1gjv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GJV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GJV FirstGlance]. <br>
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1GJV is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]] with CL, MG, K and SAP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.115 2.7.1.115]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GJV OCA]].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gjv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gjv OCA], [https://pdbe.org/1gjv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gjv RCSB], [https://www.ebi.ac.uk/pdbsum/1gjv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gjv ProSAT]</span></td></tr>
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Structure of rat BCKD kinase: nucleotide-induced domain communication in a mitochondrial protein kinase., Machius M, Chuang JL, Wynn RM, Tomchick DR, Chuang DT, Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11218-23. Epub 2001 Sep 18. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11562470 11562470]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BCKD_RAT BCKD_RAT] Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gj/1gjv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gjv ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Single protein]]
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[[Category: Chuang DT]]
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[[Category: Chuang, D.T.]]
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[[Category: Chuang JL]]
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[[Category: Chuang, J.L.]]
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[[Category: Machius M]]
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[[Category: Machius, M.]]
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[[Category: Tomchick DR]]
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[[Category: Tomchick, D.R.]]
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[[Category: Wynn MR]]
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[[Category: Wynn, R.M.]]
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[[Category: CL]]
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[[Category: K]]
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[[Category: MG]]
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[[Category: SAP]]
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[[Category: mitochondrial protein kinase]]
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[[Category: potassium]]
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[[Category: transferase]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 20:32:59 2007''
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Current revision

Branched-chain alpha-ketoacid dehydrogenase kinase (BCK) complxed with ATP-gamma-S

PDB ID 1gjv

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