1z4h

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{{Seed}}
 
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[[Image:1z4h.png|left|200px]]
 
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==The response regulator TorI belongs to a new family of atypical excisionase==
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The line below this paragraph, containing "STRUCTURE_1z4h", creates the "Structure Box" on the page.
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<StructureSection load='1z4h' size='340' side='right'caption='[[1z4h]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1z4h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z4H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z4H FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z4h OCA], [https://pdbe.org/1z4h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z4h RCSB], [https://www.ebi.ac.uk/pdbsum/1z4h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z4h ProSAT]</span></td></tr>
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{{STRUCTURE_1z4h| PDB=1z4h | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TORI_ECOLI TORI_ECOLI] Transcription inhibitory protein for the torCAD operon. Also acts as an excisionase and plays an essential role in the defective prophage CPS53 excision.<ref>PMID:15197250</ref> <ref>PMID:16079126</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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TorI (Tor inhibition protein) has been identified in Escherichia coli as a protein inhibitor acting through protein-protein interaction with the TorR response regulator. This interaction, which does not interfere with TorR DNA binding activity, probably prevents the recruitment of RNA polymerase to the torC promoter. In this study we have solved the solution structure of TorI, which adopts a prokaryotic winged-helix arrangement. Despite no primary sequence similarity, the three-dimensional structure of TorI is highly homologous to the (lambda)Xis, Mu bacteriophage repressor (MuR-DBD), and transposase (MuA-DBD) structures. We propose that the TorI protein is the structural missing link between the (lambda)Xis and MuR proteins. Moreover, in vivo assays demonstrated that TorI plays an essential role in prophage excision. Heteronuclear NMR experiments and site-directed mutagenesis studies have pinpointed out key residues involved in the DNA binding activity of TorI. Our findings suggest that TorI-related proteins identified in various pathogenic bacterial genomes define a new family of atypical excisionases.
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===The response regulator TorI belongs to a new family of atypical excisionase===
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Structural and genetic analyses reveal a key role in prophage excision for the TorI response regulator inhibitor.,Elantak L, Ansaldi M, Guerlesquin F, Mejean V, Morelli X J Biol Chem. 2005 Nov 4;280(44):36802-8. Epub 2005 Aug 2. PMID:16079126<ref>PMID:16079126</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_16079126}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1z4h" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16079126 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16079126}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1Z4H is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z4H OCA].
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==Reference==
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Structural and genetic analyses reveal a key role in prophage excision for the TorI response regulator inhibitor., Elantak L, Ansaldi M, Guerlesquin F, Mejean V, Morelli X, J Biol Chem. 2005 Nov 4;280(44):36802-8. Epub 2005 Aug 2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16079126 16079126]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Ansaldi, M.]]
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[[Category: Ansaldi M]]
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[[Category: Elantak, L.]]
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[[Category: Elantak L]]
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[[Category: Guerlesquin, F.]]
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[[Category: Guerlesquin F]]
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[[Category: Mejean, V.]]
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[[Category: Mejean V]]
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[[Category: Morelli, X.]]
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[[Category: Morelli X]]
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[[Category: Reverse turn]]
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[[Category: Winged helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:59:05 2008''
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Current revision

The response regulator TorI belongs to a new family of atypical excisionase

PDB ID 1z4h

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