1pzu

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{{Seed}}
 
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[[Image:1pzu.png|left|200px]]
 
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==An asymmetric NFAT1-RHR homodimer on a pseudo-palindromic, Kappa-B site==
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The line below this paragraph, containing "STRUCTURE_1pzu", creates the "Structure Box" on the page.
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<StructureSection load='1pzu' size='340' side='right'caption='[[1pzu]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1pzu]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PZU FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pzu OCA], [https://pdbe.org/1pzu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pzu RCSB], [https://www.ebi.ac.uk/pdbsum/1pzu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pzu ProSAT]</span></td></tr>
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{{STRUCTURE_1pzu| PDB=1pzu | SCENE= }}
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</table>
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== Function ==
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===An asymmetric NFAT1-RHR homodimer on a pseudo-palindromic, Kappa-B site===
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[https://www.uniprot.org/uniprot/NFAC2_HUMAN NFAC2_HUMAN] Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway.<ref>PMID:21871017</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_12949491}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 12949491 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pz/1pzu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_12949491}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pzu ConSurf].
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1PZU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZU OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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An asymmetric NFAT1 dimer on a pseudo-palindromic kappa B-like DNA site., Jin L, Sliz P, Chen L, Macian F, Rao A, Hogan PG, Harrison SC, Nat Struct Biol. 2003 Oct;10(10):807-11. Epub 2003 Aug 31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12949491 12949491]
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Chen, L.]]
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[[Category: Chen L]]
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[[Category: Harrison, S C.]]
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[[Category: Harrison SC]]
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[[Category: Hogan, P G.]]
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[[Category: Hogan PG]]
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[[Category: Jin, L.]]
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[[Category: Jin L]]
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[[Category: Macian, F.]]
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[[Category: Macian F]]
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[[Category: Rao, A.]]
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[[Category: Rao A]]
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[[Category: Sliz, P.]]
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[[Category: Sliz P]]
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[[Category: Human il8 promoter]]
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[[Category: Nfat1-rhr homodimer]]
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[[Category: Protein-dna complex]]
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[[Category: Transcription factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:59:15 2008''
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Current revision

An asymmetric NFAT1-RHR homodimer on a pseudo-palindromic, Kappa-B site

PDB ID 1pzu

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