This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1sjb

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:31, 14 February 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1sjb.png|left|200px]]
 
-
<!--
+
==X-ray structure of o-succinylbenzoate synthase complexed with o-succinylbenzoic acid==
-
The line below this paragraph, containing "STRUCTURE_1sjb", creates the "Structure Box" on the page.
+
<StructureSection load='1sjb' size='340' side='right'caption='[[1sjb]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1sjb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Amycolatopsis_sp. Amycolatopsis sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SJB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SJB FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OSB:2-SUCCINYLBENZOATE'>OSB</scene></td></tr>
-
{{STRUCTURE_1sjb| PDB=1sjb | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sjb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sjb OCA], [https://pdbe.org/1sjb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sjb RCSB], [https://www.ebi.ac.uk/pdbsum/1sjb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sjb ProSAT]</span></td></tr>
-
 
+
</table>
-
===X-ray structure of o-succinylbenzoate synthase complexed with o-succinylbenzoic acid===
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/NSAR_AMYSP NSAR_AMYSP] Acts as a N-succinylamino acid racemase (NSAR) that catalyzes the racemization of N-succinyl-phenylglycine and N-succinyl-methionine (PubMed:14705949, PubMed:24955846). Can catalyze the racemization of a broad range of N-acylamino acids, including N-acetyl-D/L-methionine, N-propionyl-D/L-methionine, N-butyryl-D/L-methionine and N-chloroacetyl-L-valine (PubMed:7766084, PubMed:10194342, PubMed:14705949, PubMed:23130969). Also converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB) (PubMed:10194342, PubMed:14705949, PubMed:24955846). Catalyzes both N-succinylamino acid racemization and OSB synthesis at equivalent rates (PubMed:14705949, PubMed:24955846). NSAR is probably the biological function of this enzyme (Probable).<ref>PMID:10194342</ref> <ref>PMID:14705949</ref> <ref>PMID:23130969</ref> <ref>PMID:24955846</ref> <ref>PMID:7766084</ref> <ref>PMID:16740275</ref> <ref>PMID:24955846</ref>
-
 
+
== Evolutionary Conservation ==
-
<!--
+
[[Image:Consurf_key_small.gif|200px|right]]
-
The line below this paragraph, {{ABSTRACT_PUBMED_15134446}}, adds the Publication Abstract to the page
+
Check<jmol>
-
(as it appears on PubMed at http://www.pubmed.gov), where 15134446 is the PubMed ID number.
+
<jmolCheckbox>
-
-->
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sj/1sjb_consurf.spt"</scriptWhenChecked>
-
{{ABSTRACT_PUBMED_15134446}}
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
 
+
<text>to colour the structure by Evolutionary Conservation</text>
-
==About this Structure==
+
</jmolCheckbox>
-
1SJB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Amycolatopsis_sp. Amycolatopsis sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SJB OCA].
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sjb ConSurf].
-
 
+
<div style="clear:both"></div>
-
==Reference==
+
== References ==
-
Evolution of enzymatic activity in the enolase superfamily: structural studies of the promiscuous o-succinylbenzoate synthase from Amycolatopsis., Thoden JB, Taylor Ringia EA, Garrett JB, Gerlt JA, Holden HM, Rayment I, Biochemistry. 2004 May 18;43(19):5716-27. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15134446 15134446]
+
<references/>
-
[[Category: Amycolatopsis sp.]]
+
__TOC__
-
[[Category: Single protein]]
+
</StructureSection>
-
[[Category: Garrett, J B.]]
+
[[Category: Amycolatopsis sp]]
-
[[Category: Gerlt, J A.]]
+
[[Category: Large Structures]]
-
[[Category: Holden, H M.]]
+
[[Category: Garrett JB]]
-
[[Category: Rayment, I.]]
+
[[Category: Gerlt JA]]
-
[[Category: Taylor-Ringia, E A.]]
+
[[Category: Holden HM]]
-
[[Category: Thoden, J B.]]
+
[[Category: Rayment I]]
-
[[Category: Racemase]]
+
[[Category: Taylor-Ringia EA]]
-
 
+
[[Category: Thoden JB]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:09:18 2008''
+

Current revision

X-ray structure of o-succinylbenzoate synthase complexed with o-succinylbenzoic acid

PDB ID 1sjb

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1sjb"
Personal tools