This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1yn6

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:04, 15 May 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1yn6.png|left|200px]]
 
-
<!--
+
==Crystal structure of a mouse MHC class I protein, H2-Db, in complex with a peptide from the influenza A acid polymerase==
-
The line below this paragraph, containing "STRUCTURE_1yn6", creates the "Structure Box" on the page.
+
<StructureSection load='1yn6' size='340' side='right'caption='[[1yn6]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1yn6]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/swine/Iowa/15/1930(H1N1)) Influenza A virus (A/swine/Iowa/15/1930(H1N1))] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YN6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YN6 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yn6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yn6 OCA], [https://pdbe.org/1yn6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yn6 RCSB], [https://www.ebi.ac.uk/pdbsum/1yn6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yn6 ProSAT]</span></td></tr>
-
{{STRUCTURE_1yn6| PDB=1yn6 | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/PA_I30A0 PA_I30A0] Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits. The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching. It consists in the hijacking and cleavage of host capped pre-mRNAs. These short capped RNAs are then used as primers for viral mRNAs. The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity. In addition of its function in viral transcription, PA also plays an essential role in viral RNA synthesis and promotes the formation of the trimeric polymerase complex.[UniProtKB:P03433]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yn/1yn6_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yn6 ConSurf].
 +
<div style="clear:both"></div>
-
===Crystal structure of a mouse MHC class I protein, H2-Db, in complex with a peptide from the influenza A acid polymerase===
+
==See Also==
-
 
+
*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
-
 
+
*[[MHC 3D structures|MHC 3D structures]]
-
==About this Structure==
+
*[[MHC I 3D structures|MHC I 3D structures]]
-
1YN6 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YN6 OCA].
+
__TOC__
-
 
+
</StructureSection>
-
==Reference==
+
[[Category: Large Structures]]
-
Favorite flavors of surfaces., Jones EY, Nat Immunol. 2005 Apr;6(4):365-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15785764 15785764]
+
[[Category: Mus musculus]]
[[Category: Mus musculus]]
-
[[Category: Protein complex]]
+
[[Category: Doherty PC]]
-
[[Category: RNA-directed RNA polymerase]]
+
[[Category: Dunstone MA]]
-
[[Category: Doherty, P C.]]
+
[[Category: Kedzierska K]]
-
[[Category: Dunstone, M A.]]
+
[[Category: Komodromou H]]
-
[[Category: Gruta, N L.La.]]
+
[[Category: La Gruta NL]]
-
[[Category: Kedzierska, K.]]
+
[[Category: McCluskey J]]
-
[[Category: Komodromou, H.]]
+
[[Category: Purcell AW]]
-
[[Category: McCluskey, J.]]
+
[[Category: Rossjohn J]]
-
[[Category: Purcell, A W.]]
+
[[Category: Turner SJ]]
-
[[Category: Rossjohn, J.]]
+
[[Category: Walden H]]
-
[[Category: Turner, S J.]]
+
[[Category: Webb AI]]
-
[[Category: Walden, H.]]
+
[[Category: Webby R]]
-
[[Category: Webb, A I.]]
+
[[Category: Xie W]]
-
[[Category: Webby, R.]]
+
-
[[Category: Xie, W.]]
+
-
[[Category: H2-db]]
+
-
[[Category: Influenza some]]
+
-
[[Category: Mhc class 1]]
+
-
[[Category: Peptide of acid polymerase]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:13:20 2008''
+

Current revision

Crystal structure of a mouse MHC class I protein, H2-Db, in complex with a peptide from the influenza A acid polymerase

PDB ID 1yn6

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1yn6"
Personal tools