1r1o

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{{Seed}}
 
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[[Image:1r1o.png|left|200px]]
 
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==Amino Acid Sulfonamides as Transition-State Analogue Inhibitors of Arginase==
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The line below this paragraph, containing "STRUCTURE_1r1o", creates the "Structure Box" on the page.
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<StructureSection load='1r1o' size='340' side='right'caption='[[1r1o]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1r1o]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R1O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R1O FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SDC:S-[2-(AMINOSULFONYL)ETHYL]-D-CYSTEINE'>SDC</scene></td></tr>
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{{STRUCTURE_1r1o| PDB=1r1o | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r1o OCA], [https://pdbe.org/1r1o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r1o RCSB], [https://www.ebi.ac.uk/pdbsum/1r1o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r1o ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ARGI1_RAT ARGI1_RAT]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r1/1r1o_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r1o ConSurf].
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<div style="clear:both"></div>
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===Amino Acid Sulfonamides as Transition-State Analogue Inhibitors of Arginase===
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==See Also==
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*[[Arginase 3D structures|Arginase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_14570477}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 14570477 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14570477}}
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==About this Structure==
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1R1O is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R1O OCA].
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==Reference==
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Design of amino acid sulfonamides as transition-state analogue inhibitors of arginase., Cama E, Shin H, Christianson DW, J Am Chem Soc. 2003 Oct 29;125(43):13052-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14570477 14570477]
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[[Category: Arginase]]
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Single protein]]
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[[Category: Cama E]]
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[[Category: Cama, E.]]
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[[Category: Christianson DW]]
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[[Category: Christianson, D W.]]
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[[Category: Shin H]]
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[[Category: Shin, H.]]
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[[Category: Arginase]]
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[[Category: Hydrolase]]
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[[Category: Sulfonamide]]
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[[Category: Transition-state analogue]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:15:23 2008''
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Current revision

Amino Acid Sulfonamides as Transition-State Analogue Inhibitors of Arginase

PDB ID 1r1o

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