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1mxc

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{{Seed}}
 
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[[Image:1mxc.png|left|200px]]
 
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==S-ADENOSYLMETHIONINE SYNTHETASE WITH 8-BR-ADP==
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The line below this paragraph, containing "STRUCTURE_1mxc", creates the "Structure Box" on the page.
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<StructureSection load='1mxc' size='340' side='right'caption='[[1mxc]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1mxc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MXC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MXC FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABP:8-BROMOADENOSINE-5-DIPHOSPHATE'>ABP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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{{STRUCTURE_1mxc| PDB=1mxc | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mxc OCA], [https://pdbe.org/1mxc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mxc RCSB], [https://www.ebi.ac.uk/pdbsum/1mxc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mxc ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/METK_ECOLI METK_ECOLI] Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. Is essential for growth.[HAMAP-Rule:MF_00086]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mx/1mxc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mxc ConSurf].
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<div style="clear:both"></div>
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===S-ADENOSYLMETHIONINE SYNTHETASE WITH 8-BR-ADP===
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==See Also==
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*[[S-adenosylmethionine synthetase 3D structures|S-adenosylmethionine synthetase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_8611562}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8611562 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8611562}}
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==About this Structure==
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1MXC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MXC OCA].
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==Reference==
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Structure and function of S-adenosylmethionine synthetase: crystal structures of S-adenosylmethionine synthetase with ADP, BrADP, and PPi at 28 angstroms resolution., Takusagawa F, Kamitori S, Markham GD, Biochemistry. 1996 Feb 27;35(8):2586-96. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8611562 8611562]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Methionine adenosyltransferase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Kamitori S]]
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[[Category: Kamitori, S.]]
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[[Category: Markham GD]]
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[[Category: Markham, G D.]]
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[[Category: Takusagawa F]]
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[[Category: Takusagawa, F.]]
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[[Category: Atp-binding]]
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[[Category: One-carbon metabolism]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:17:10 2008''
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Current revision

S-ADENOSYLMETHIONINE SYNTHETASE WITH 8-BR-ADP

PDB ID 1mxc

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