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1n4y

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(New page: 200px<br /><applet load="1n4y" size="450" color="white" frame="true" align="right" spinBox="true" caption="1n4y" /> '''REFINED STRUCTURE OF KISTRIN'''<br /> ==Ove...)
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[[Image:1n4y.gif|left|200px]]<br /><applet load="1n4y" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1n4y" />
 
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'''REFINED STRUCTURE OF KISTRIN'''<br />
 
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==Overview==
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==REFINED STRUCTURE OF KISTRIN==
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The structure of kistrin, which is a member of a homologous family of, glycoprotein IIb-IIIa (GP IIb-IIIa) antagonists and potent protein, inhibitors of platelet aggregation, has been determined by two-dimensional, nuclear magnetic resonance (NMR) spectroscopy. The 68-residue protein, consists of a series of tightly packed loops held together by six, disulfide bonds and has almost no regular secondary structure. Kistrin has, an Arg-Gly-Asp (RGD) adhesion site recognition sequence important for, binding to GP IIb-IIIa that is located at the apex of a long loop across, the surface of the protein.
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<StructureSection load='1n4y' size='340' side='right'caption='[[1n4y]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1n4y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Calloselasma_rhodostoma Calloselasma rhodostoma]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1kst 1kst]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N4Y FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n4y OCA], [https://pdbe.org/1n4y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n4y RCSB], [https://www.ebi.ac.uk/pdbsum/1n4y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n4y ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VM2RH_CALRH VM2RH_CALRH] Metalloproteinase rhodostoxin: snake venom metalloproteinase that impairs hemostasis in the envenomed animal (By similarity). Disintegrin rhodostomin: inhibit platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n4/1n4y_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n4y ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1N4Y is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Calloselasma_rhodostoma Calloselasma rhodostoma]. This structure superseeds the now removed PDB entry 1KST. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1N4Y OCA].
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*[[Disintegrin|Disintegrin]]
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__TOC__
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==Reference==
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</StructureSection>
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Solution structure of kistrin, a potent platelet aggregation inhibitor and GP IIb-IIIa antagonist., Adler M, Lazarus RA, Dennis MS, Wagner G, Science. 1991 Jul 26;253(5018):445-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1862345 1862345]
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[[Category: Calloselasma rhodostoma]]
[[Category: Calloselasma rhodostoma]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Dennis, M.S.]]
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[[Category: Dennis MS]]
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[[Category: Krane, J.]]
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[[Category: Krane J]]
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[[Category: Krezel, A.M.]]
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[[Category: Krezel AM]]
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[[Category: Lazarus, R.A.]]
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[[Category: Lazarus RA]]
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[[Category: Wagner, G.]]
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[[Category: Wagner G]]
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[[Category: beta]]
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[[Category: blood coagulation]]
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[[Category: rgd]]
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[[Category: venom]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 21:58:02 2007''
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Current revision

REFINED STRUCTURE OF KISTRIN

PDB ID 1n4y

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