2r02

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{{Seed}}
 
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[[Image:2r02.png|left|200px]]
 
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==Crystal Structure of ALIX/AIP1 in complex with the HIV-1 YPLTSL Late Domain==
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The line below this paragraph, containing "STRUCTURE_2r02", creates the "Structure Box" on the page.
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<StructureSection load='2r02' size='340' side='right'caption='[[2r02]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2r02]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/HIV-1_M:J_SE9173 HIV-1 M:J_SE9173] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R02 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R02 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r02 OCA], [https://pdbe.org/2r02 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r02 RCSB], [https://www.ebi.ac.uk/pdbsum/2r02 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r02 ProSAT]</span></td></tr>
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{{STRUCTURE_2r02| PDB=2r02 | SCENE= }}
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</table>
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== Function ==
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===Crystal Structure of ALIX/AIP1 in complex with the HIV-1 YPLTSL Late Domain===
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[https://www.uniprot.org/uniprot/PDC6I_HUMAN PDC6I_HUMAN] Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Appears to be an adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis. Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function implies the interaction with CHMP4B. May play a role in the regulation of both apoptosis and cell proliferation.<ref>PMID:14505569</ref> <ref>PMID:14505570</ref> <ref>PMID:14739459</ref> <ref>PMID:17853893</ref> <ref>PMID:17428861</ref> <ref>PMID:17556548</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_18066081}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 18066081 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r0/2r02_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_18066081}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r02 ConSurf].
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2R02 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R02 OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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Structural and functional studies of ALIX interactions with YPX(n)L late domains of HIV-1 and EIAV., Zhai Q, Fisher RD, Chung HY, Myszka DG, Sundquist WI, Hill CP, Nat Struct Mol Biol. 2008 Jan;15(1):43-9. Epub 2007 Dec 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18066081 18066081]
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__TOC__
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</StructureSection>
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[[Category: HIV-1 M:J_SE9173]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Fisher, R D.]]
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[[Category: Fisher RD]]
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[[Category: Hill, C P.]]
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[[Category: Hill CP]]
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[[Category: Zhai, Q.]]
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[[Category: Zhai Q]]
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[[Category: Aid]]
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[[Category: Apoptosis]]
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[[Category: Capsid protein]]
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[[Category: Coiled-coil]]
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[[Category: Cytoplasm]]
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[[Category: Host-virus interaction]]
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[[Category: Lipoprotein]]
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[[Category: Membrane]]
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[[Category: Metal-binding]]
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[[Category: Myristate]]
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[[Category: Nucleus]]
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[[Category: Peptide]]
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[[Category: Phosphorylation]]
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[[Category: Polymorphism]]
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[[Category: Protein transport]]
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[[Category: Rna-binding]]
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[[Category: Transport]]
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[[Category: Viral nucleoprotein]]
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[[Category: Virion]]
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[[Category: Zinc]]
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[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:23:32 2008''
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Current revision

Crystal Structure of ALIX/AIP1 in complex with the HIV-1 YPLTSL Late Domain

PDB ID 2r02

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