1yty

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{{Seed}}
 
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[[Image:1yty.png|left|200px]]
 
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==Structural basis for recognition of UUUOH 3'-terminii of nascent RNA pol III transcripts by La autoantigen==
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The line below this paragraph, containing "STRUCTURE_1yty", creates the "Structure Box" on the page.
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<StructureSection load='1yty' size='340' side='right'caption='[[1yty]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1yty]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YTY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YTY FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.29&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_1yty| PDB=1yty | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yty OCA], [https://pdbe.org/1yty PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yty RCSB], [https://www.ebi.ac.uk/pdbsum/1yty PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yty ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yt/1yty_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yty ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The nuclear phosphoprotein La was identified as an autoantigen in patients with systemic lupus erythematosus and Sjogren's syndrome. La binds to and protects the UUU(OH) 3' terminii of nascent RNA polymerase III transcripts from exonuclease digestion. We report the 1.85 angstroms crystal structure of the N-terminal domain of human La, consisting of La and RRM1 motifs, bound to r(U1-G2-C3-U4-G5-U6-U7-U8-U9OH). The U7-U8-U9OH 3' end, in a splayed-apart orientation, is sequestered within a basic and aromatic amino acid-lined cleft between the La and RRM1 motifs. The specificity-determining U8 residue bridges both motifs, in part through unprecedented targeting of the beta sheet edge, rather than the anticipated face, of the RRM1 motif. Our structural observations, supported by mutation studies of both La and RNA components, illustrate the principles behind RNA sequestration by a rheumatic disease autoantigen, whereby the UUU(OH) 3' ends of nascent RNA transcripts are protected during downstream processing and maturation events.
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===Structural basis for recognition of UUUOH 3'-terminii of nascent RNA pol III transcripts by La autoantigen===
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Structural basis for recognition and sequestration of UUU(OH) 3' temini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen.,Teplova M, Yuan YR, Phan AT, Malinina L, Ilin S, Teplov A, Patel DJ Mol Cell. 2006 Jan 6;21(1):75-85. PMID:16387655<ref>PMID:16387655</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_16387655}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1yty" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16387655 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16387655}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1YTY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YTY OCA].
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==Reference==
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Structural basis for recognition and sequestration of UUU(OH) 3' temini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen., Teplova M, Yuan YR, Phan AT, Malinina L, Ilin S, Teplov A, Patel DJ, Mol Cell. 2006 Jan 6;21(1):75-85. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16387655 16387655]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Ilin, S.]]
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[[Category: Ilin S]]
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[[Category: Malinina, L.]]
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[[Category: Malinina L]]
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[[Category: Patel, D J.]]
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[[Category: Patel DJ]]
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[[Category: Phan, A T.]]
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[[Category: Phan AT]]
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[[Category: Teplov, A.]]
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[[Category: Teplov A]]
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[[Category: Teplova, M.]]
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[[Category: Teplova M]]
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[[Category: Yuan, Y R.]]
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[[Category: Yuan YR]]
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[[Category: Protein-rna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:33:57 2008''
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Current revision

Structural basis for recognition of UUUOH 3'-terminii of nascent RNA pol III transcripts by La autoantigen

PDB ID 1yty

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