2nrc

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{{Seed}}
 
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[[Image:2nrc.png|left|200px]]
 
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==C28A Mutant of Succinyl-CoA:3-Ketoacid CoA Transferase from Pig Heart==
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The line below this paragraph, containing "STRUCTURE_2nrc", creates the "Structure Box" on the page.
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<StructureSection load='2nrc' size='340' side='right'caption='[[2nrc]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2nrc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NRC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NRC FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nrc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nrc OCA], [https://pdbe.org/2nrc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nrc RCSB], [https://www.ebi.ac.uk/pdbsum/2nrc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nrc ProSAT]</span></td></tr>
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{{STRUCTURE_2nrc| PDB=2nrc | SCENE= }}
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</table>
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== Function ==
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===C28A Mutant of Succinyl-CoA:3-Ketoacid CoA Transferase from Pig Heart===
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[https://www.uniprot.org/uniprot/SCOT1_PIG SCOT1_PIG] Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_17718512}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 17718512 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nr/2nrc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_17718512}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2nrc ConSurf].
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2NRC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NRC OCA].
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<div style="clear:both"></div>
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__TOC__
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==Reference==
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</StructureSection>
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Identification of the cysteine residue exposed by the conformational change in pig heart succinyl-CoA:3-ketoacid coenzyme A transferase on binding coenzyme A., Tammam SD, Rochet JC, Fraser ME, Biochemistry. 2007 Sep 25;46(38):10852-63. Epub 2007 Aug 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17718512 17718512]
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[[Category: Large Structures]]
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[[Category: 3-oxoacid CoA-transferase]]
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[[Category: Single protein]]
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[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
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[[Category: Fraser, M E.]]
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[[Category: Fraser ME]]
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[[Category: Tammam, S D.]]
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[[Category: Tammam SD]]
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[[Category: Alpha/beta protein]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:36:21 2008''
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Current revision

C28A Mutant of Succinyl-CoA:3-Ketoacid CoA Transferase from Pig Heart

PDB ID 2nrc

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