2cky

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{{Seed}}
 
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[[Image:2cky.png|left|200px]]
 
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==Structure of the Arabidopsis thaliana thiamine pyrophosphate riboswitch with its regulatory ligand==
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The line below this paragraph, containing "STRUCTURE_2cky", creates the "Structure Box" on the page.
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<StructureSection load='2cky' size='340' side='right'caption='[[2cky]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2cky]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CKY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CKY FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OS:OSMIUM+ION'>OS</scene>, <scene name='pdbligand=TPP:THIAMINE+DIPHOSPHATE'>TPP</scene></td></tr>
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{{STRUCTURE_2cky| PDB=2cky | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cky OCA], [https://pdbe.org/2cky PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cky RCSB], [https://www.ebi.ac.uk/pdbsum/2cky PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cky ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Riboswitches are untranslated regions of messenger RNA, which adopt alternate structures depending on the binding of specific metabolites. Such conformational switching regulates the expression of proteins involved in the biosynthesis of riboswitch substrates. Here, we present the 2.9 angstrom-resolution crystal structure of the eukaryotic Arabidopsis thaliana thiamine pyrophosphate (TPP)-specific riboswitch in complex with its natural ligand. The riboswitch specifically recognizes the TPP via conserved residues located within two highly distorted parallel "sensor" helices. The structure provides the basis for understanding the reorganization of the riboswitch fold upon TPP binding and explains the mechanism of resistance to the antibiotic pyrithiamine.
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===Structure of the arabidopsis thaliana thiamine pyrophosphate riboswitch with its regulatory ligand===
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Structure of the eukaryotic thiamine pyrophosphate riboswitch with its regulatory ligand.,Thore S, Leibundgut M, Ban N Science. 2006 May 26;312(5777):1208-11. Epub 2006 May 4. PMID:16675665<ref>PMID:16675665</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2cky" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_16675665}}, adds the Publication Abstract to the page
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*[[Riboswitch 3D structures|Riboswitch 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 16675665 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16675665}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Arabidopsis thaliana]]
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2CKY is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CKY OCA].
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[[Category: Large Structures]]
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[[Category: Ban N]]
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==Reference==
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[[Category: Leibundgut M]]
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Structure of the eukaryotic thiamine pyrophosphate riboswitch with its regulatory ligand., Thore S, Leibundgut M, Ban N, Science. 2006 May 26;312(5777):1208-11. Epub 2006 May 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16675665 16675665]
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[[Category: Thore S]]
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[[Category: Single protein]]
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[[Category: Ban, N.]]
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[[Category: Leibundgut, M.]]
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[[Category: Thore, S.]]
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[[Category: Nucleic acid]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:37:41 2008''
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Current revision

Structure of the Arabidopsis thaliana thiamine pyrophosphate riboswitch with its regulatory ligand

PDB ID 2cky

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