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1ms6

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{{Seed}}
 
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[[Image:1ms6.png|left|200px]]
 
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<!--
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==Dipeptide Nitrile Inhibitor Bound to Cathepsin S.==
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The line below this paragraph, containing "STRUCTURE_1ms6", creates the "Structure Box" on the page.
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<StructureSection load='1ms6' size='340' side='right'caption='[[1ms6]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ms6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MS6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MS6 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BLN:MORPHOLINE-4-CARBOXYLIC+ACID+[1S-(2-BENZYLOXY-1R-CYANO-ETHYLCARBAMOYL)-3-METHYL-BUTYL]AMIDE'>BLN</scene></td></tr>
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{{STRUCTURE_1ms6| PDB=1ms6 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ms6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ms6 OCA], [https://pdbe.org/1ms6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ms6 RCSB], [https://www.ebi.ac.uk/pdbsum/1ms6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ms6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CATS_HUMAN CATS_HUMAN] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ms/1ms6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ms6 ConSurf].
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<div style="clear:both"></div>
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===Dipeptide Nitrile Inhibitor Bound to Cathepsin S.===
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==See Also==
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*[[Cathepsin 3D structures|Cathepsin 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_12459015}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12459015 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12459015}}
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==About this Structure==
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1MS6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MS6 OCA].
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==Reference==
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Design and synthesis of dipeptide nitriles as reversible and potent Cathepsin S inhibitors., Ward YD, Thomson DS, Frye LL, Cywin CL, Morwick T, Emmanuel MJ, Zindell R, McNeil D, Bekkali Y, Girardot M, Hrapchak M, DeTuri M, Crane K, White D, Pav S, Wang Y, Hao MH, Grygon CA, Labadia ME, Freeman DM, Davidson W, Hopkins JL, Brown ML, Spero DM, J Med Chem. 2002 Dec 5;45(25):5471-82. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12459015 12459015]
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[[Category: Cathepsin S]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bekkali, Y.]]
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[[Category: Bekkali Y]]
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[[Category: Brown, M L.]]
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[[Category: Brown ML]]
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[[Category: Crane, K.]]
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[[Category: Crane K]]
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[[Category: Cywin, C L.]]
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[[Category: Cywin CL]]
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[[Category: Davidson, W.]]
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[[Category: Davidson W]]
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[[Category: DeTuri, M.]]
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[[Category: DeTuri M]]
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[[Category: Emmanuel, M J.]]
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[[Category: Emmanuel MJ]]
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[[Category: Freeman, D M.]]
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[[Category: Freeman DM]]
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[[Category: Frye, L L.]]
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[[Category: Frye LL]]
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[[Category: Giradot, M.]]
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[[Category: Giradot M]]
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[[Category: Grygon, C A.]]
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[[Category: Grygon CA]]
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[[Category: Hao, M H.]]
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[[Category: Hao MH]]
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[[Category: Hopkins, J L.]]
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[[Category: Hopkins JL]]
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[[Category: Hrapchak, M.]]
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[[Category: Hrapchak M]]
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[[Category: Labadia, M E.]]
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[[Category: Labadia ME]]
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[[Category: McNeil, D.]]
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[[Category: McNeil D]]
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[[Category: Morwick, T.]]
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[[Category: Morwick T]]
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[[Category: Pav, S.]]
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[[Category: Pav S]]
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[[Category: Spero, D M.]]
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[[Category: Spero DM]]
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[[Category: Thomson, D S.]]
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[[Category: Thomson DS]]
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[[Category: Wang, Y.]]
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[[Category: Wang Y]]
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[[Category: Ward, Y D.]]
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[[Category: Ward YD]]
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[[Category: White, D.]]
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[[Category: White D]]
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[[Category: Zindell, R.]]
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[[Category: Zindell R]]
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[[Category: Cathepsin]]
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[[Category: Hydrolase]]
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[[Category: Protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:41:35 2008''
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Current revision

Dipeptide Nitrile Inhibitor Bound to Cathepsin S.

PDB ID 1ms6

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