2cvq

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{{Seed}}
 
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[[Image:2cvq.png|left|200px]]
 
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==Crystal structure of NAD(H)-dependent malate dehydrogenase complexed with NADPH==
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The line below this paragraph, containing "STRUCTURE_2cvq", creates the "Structure Box" on the page.
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<StructureSection load='2cvq' size='340' side='right'caption='[[2cvq]], [[Resolution|resolution]] 2.08&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2cvq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CVQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CVQ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.08&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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{{STRUCTURE_2cvq| PDB=2cvq | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cvq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cvq OCA], [https://pdbe.org/2cvq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cvq RCSB], [https://www.ebi.ac.uk/pdbsum/2cvq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cvq ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MDH_THETH MDH_THETH] Catalyzes the reversible oxidation of malate to oxaloacetate.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cv/2cvq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cvq ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of NAD(H)-dependent malate dehydrogenase complexed with NADPH===
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==See Also==
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*[[Malate Dehydrogenase 3D structures|Malate Dehydrogenase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_16009341}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 16009341 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16009341}}
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==About this Structure==
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2CVQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CVQ OCA].
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==Reference==
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Crystal structure of NAD-dependent malate dehydrogenase complexed with NADP(H)., Tomita T, Fushinobu S, Kuzuyama T, Nishiyama M, Biochem Biophys Res Commun. 2005 Aug 26;334(2):613-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16009341 16009341]
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Determinants of protein thermostability observed in the 1.9-A crystal structure of malate dehydrogenase from the thermophilic bacterium Thermus flavus., Kelly CA, Nishiyama M, Ohnishi Y, Beppu T, Birktoft JJ, Biochemistry. 1993 Apr 20;32(15):3913-22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8471603 8471603]
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Preliminary X-ray diffraction analysis of a crystallizable mutant of malate dehydrogenase from the thermophile Thermus flavus., Kelly CA, Sarfaty S, Nishiyama M, Beppu T, Birktoft JJ, J Mol Biol. 1991 Sep 20;221(2):383-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1920425 1920425]
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Refined crystal structure of cytoplasmic malate dehydrogenase at 2.5-A resolution., Birktoft JJ, Rhodes G, Banaszak LJ, Biochemistry. 1989 Jul 11;28(14):6065-81. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/2775751 2775751]
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Nucleotide sequence of the malate dehydrogenase gene of Thermus flavus and its mutation directing an increase in enzyme activity., Nishiyama M, Matsubara N, Yamamoto K, Iijima S, Uozumi T, Beppu T, J Biol Chem. 1986 Oct 25;261(30):14178-83. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/3771528 3771528]
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The presence of a histidine-aspartic acid pair in the active site of 2-hydroxyacid dehydrogenases. X-ray refinement of cytoplasmic malate dehydrogenase., Birktoft JJ, Banaszak LJ, J Biol Chem. 1983 Jan 10;258(1):472-82. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/6848515 6848515]
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[[Category: Malate dehydrogenase]]
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[[Category: Single protein]]
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[[Category: Thermus thermophilus]]
[[Category: Thermus thermophilus]]
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[[Category: Fushinobu, S.]]
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[[Category: Fushinobu S]]
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[[Category: Kuzuyama, T.]]
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[[Category: Kuzuyama T]]
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[[Category: Nishiyama, M.]]
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[[Category: Nishiyama M]]
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[[Category: Tomita, T.]]
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[[Category: Tomita T]]
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[[Category: Nad-dependent-mdh nadp+ complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:41:37 2008''
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Current revision

Crystal structure of NAD(H)-dependent malate dehydrogenase complexed with NADPH

PDB ID 2cvq

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