2rck

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{{Seed}}
 
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[[Image:2rck.png|left|200px]]
 
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==Crystal structure of juvenile hormone binding protein from Galleria mellonella hemolymph==
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The line below this paragraph, containing "STRUCTURE_2rck", creates the "Structure Box" on the page.
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<StructureSection load='2rck' size='340' side='right'caption='[[2rck]], [[Resolution|resolution]] 2.44&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2rck]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Galleria_mellonella Galleria mellonella]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RCK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RCK FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.44&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_2rck| PDB=2rck | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rck FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rck OCA], [https://pdbe.org/2rck PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rck RCSB], [https://www.ebi.ac.uk/pdbsum/2rck PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rck ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8ITP4_GALME Q8ITP4_GALME]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rc/2rck_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rck ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Low molecular weight juvenile hormone binding proteins (JHBPs) are specific carriers of juvenile hormone (JH) in the hemolymph of butterflies and moths. As hormonal signal transmitters, these proteins exert a profound effect on insect development. The crystal structure of JHBP from Galleria mellonella shows an unusual fold consisting of a long alpha-helix wrapped in a highly curved antiparallel beta-sheet. JHBP structurally resembles the folding pattern found in tandem repeats in some mammalian lipid-binding proteins, with similar organization of one cavity and a disulfide bond between the long helix and the beta-sheet. JHBP reveals, therefore, an archetypal fold used by nature for hydrophobic ligand binding. The JHBP molecule possesses two hydrophobic cavities. Several lines of experimental evidence conclusively indicate that JHBP binds JH in only one cavity, close to the N- and C-termini, and that this binding induces a structural change. The second cavity, located at the opposite end of the molecule, could bind another ligand.
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===Crystal structure of juvenile hormone binding protein from Galleria mellonella hemolymph===
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Insect juvenile hormone binding protein shows ancestral fold present in human lipid-binding proteins.,Kolodziejczyk R, Bujacz G, Jakob M, Ozyhar A, Jaskolski M, Kochman M J Mol Biol. 2008 Mar 28;377(3):870-81. Epub 2008 Jan 16. PMID:18291417<ref>PMID:18291417</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_18291417}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2rck" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 18291417 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18291417}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2RCK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Galleria_mellonella Galleria mellonella]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RCK OCA].
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==Reference==
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Insect Juvenile Hormone Binding Protein Shows Ancestral Fold Present in Human Lipid-Binding Proteins., Kolodziejczyk R, Bujacz G, Jakob M, Ozyhar A, Jaskolski M, Kochman M, J Mol Biol. 2008 Jan 16;. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18291417 18291417]
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[[Category: Galleria mellonella]]
[[Category: Galleria mellonella]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bujacz, G.]]
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[[Category: Bujacz G]]
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[[Category: Jakob, M.]]
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[[Category: Jakob M]]
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[[Category: Jaskolski, M.]]
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[[Category: Jaskolski M]]
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[[Category: Kochman, M.]]
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[[Category: Kochman M]]
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[[Category: Kolodziejczyk, R.]]
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[[Category: Kolodziejczyk R]]
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[[Category: Ozyhar, A.]]
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[[Category: Ozyhar A]]
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[[Category: Galleria mellonella]]
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[[Category: Hemolymph]]
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[[Category: Hormone binding protein]]
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[[Category: Jhbp-fold]]
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[[Category: Juvenile hormone]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:50:27 2008''
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Current revision

Crystal structure of juvenile hormone binding protein from Galleria mellonella hemolymph

PDB ID 2rck

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OCA

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