1qvw

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{{Seed}}
 
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[[Image:1qvw.png|left|200px]]
 
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==Crystal structure of the S. cerevisiae YDR533c protein==
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The line below this paragraph, containing "STRUCTURE_1qvw", creates the "Structure Box" on the page.
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<StructureSection load='1qvw' size='340' side='right'caption='[[1qvw]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1qvw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QVW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QVW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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{{STRUCTURE_1qvw| PDB=1qvw | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qvw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qvw OCA], [https://pdbe.org/1qvw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qvw RCSB], [https://www.ebi.ac.uk/pdbsum/1qvw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qvw ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HSP31_YEAST HSP31_YEAST] Probable protease. May act as a chaperone.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qv/1qvw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qvw ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The ORF YDR533c from Saccharomyces cerevisiae codes for a 25.5 kDa protein of unknown biochemical function. Transcriptome analysis of yeast has shown that this gene is activated in response to various stress conditions together with proteins belonging to the heat shock family. In order to clarify its biochemical function, we determined the crystal structure of YDR533c to 1.85 A resolution by the single anomalous diffraction method. The protein possesses an alpha/beta hydrolase fold and a putative Cys-His-Glu catalytic triad common to a large enzyme family containing proteases, amidotransferases, lipases, and esterases. The protein has strong structural resemblance with the E. coli Hsp31 protein and the intracellular protease I from Pyrococcus horikoshii, which are considered class I and class III members of the Hsp31 family, respectively. Detailed structural analysis strongly suggests that the YDR533c protein crystal structure is the first one of a class II member of the Hsp31 family.
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===Crystal structure of the S. cerevisiae YDR533c protein===
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Crystal structure of the YDR533c S. cerevisiae protein, a class II member of the Hsp31 family.,Graille M, Quevillon-Cheruel S, Leulliot N, Zhou CZ, de la Sierra Gallay IL, Jacquamet L, Ferrer JL, Liger D, Poupon A, Janin J, van Tilbeurgh H Structure. 2004 May;12(5):839-47. PMID:15130476<ref>PMID:15130476</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15130476}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1qvw" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15130476 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15130476}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1QVW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QVW OCA].
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==Reference==
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Crystal structure of the YDR533c S. cerevisiae protein, a class II member of the Hsp31 family., Graille M, Quevillon-Cheruel S, Leulliot N, Zhou CZ, de la Sierra Gallay IL, Jacquamet L, Ferrer JL, Liger D, Poupon A, Janin J, van Tilbeurgh H, Structure. 2004 May;12(5):839-47. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15130476 15130476]
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Single protein]]
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[[Category: Graille M]]
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[[Category: Graille, M.]]
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[[Category: Leulliot N]]
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[[Category: Leulliot, N.]]
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[[Category: Quevillon-Cheruel S]]
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[[Category: Quevillon-Cheruel, S.]]
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[[Category: Van Tilbeurgh H]]
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[[Category: Tilbeurgh, H van.]]
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[[Category: Alpha/beta hydrolase fold]]
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[[Category: Catalytic triad]]
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[[Category: Heat shock protein]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:57:36 2008''
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Current revision

Crystal structure of the S. cerevisiae YDR533c protein

PDB ID 1qvw

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