1n93

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(New page: 200px<br /><applet load="1n93" size="450" color="white" frame="true" align="right" spinBox="true" caption="1n93, resolution 1.76&Aring;" /> '''Crystal Structure of...)
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[[Image:1n93.gif|left|200px]]<br /><applet load="1n93" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1n93, resolution 1.76&Aring;" />
 
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'''Crystal Structure of the Borna Disease Virus Nucleoprotein'''<br />
 
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==Overview==
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==Crystal Structure of the Borna Disease Virus Nucleoprotein==
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Borna disease virus (BDV) causes an infection of the central nervous, system in a wide range of vertebrates, which can fatally progress to an, immune-mediated disease, called Borna disease. BDV is a member of the, Mononegavirales, which also includes the highly infectious measles and, Ebola viruses. The viral nucleoproteins are central to transcription, replication, and packaging of the RNA genome. We present the X-ray, structure of the BDV nucleoprotein determined at 1.76 A resolution. The, structure reveals a novel fold, organized into two distinct domains, and, an assembly into a planar homotetramer. Surface potential calculations, strongly support an RNA binding model with the RNA wrapping around the, outside of the tetramer, although a positively charged central channel in, the tetramer could fit single-stranded RNA in an alternative binding mode., This first structure of an RNA virus nucleoprotein provides a paradigmatic, model for RNA packaging and replication of single-stranded RNA viruses.
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<StructureSection load='1n93' size='340' side='right'caption='[[1n93]], [[Resolution|resolution]] 1.76&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1n93]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Borna_disease_virus Borna disease virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N93 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N93 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.76&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n93 OCA], [https://pdbe.org/1n93 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n93 RCSB], [https://www.ebi.ac.uk/pdbsum/1n93 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n93 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NCAP_BDV1 NCAP_BDV1] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. Targets viral NC to the nucleus. Could be involved in the transport of nucleoprotein particles from the nucleus to the cytoplasm. The nuclear export signal is masked by the interaction with the P protein.<ref>PMID:11238866</ref>
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==About this Structure==
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==See Also==
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1N93 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Borna_disease_virus Borna disease virus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1N93 OCA].
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*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
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== References ==
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==Reference==
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<references/>
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Crystal structure of the borna disease virus nucleoprotein., Rudolph MG, Kraus I, Dickmanns A, Eickmann M, Garten W, Ficner R, Structure. 2003 Oct;11(10):1219-26. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14527390 14527390]
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__TOC__
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</StructureSection>
[[Category: Borna disease virus]]
[[Category: Borna disease virus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Dickmanns, A.]]
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[[Category: Dickmanns A]]
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[[Category: Ficner, R.]]
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[[Category: Ficner R]]
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[[Category: Garten, W.]]
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[[Category: Garten W]]
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[[Category: Kraus, I.]]
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[[Category: Kraus I]]
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[[Category: Rudolph, M.G.]]
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[[Category: Rudolph MG]]
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[[Category: rna virus nucleoprotein tetramer]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 22:03:59 2007''
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Current revision

Crystal Structure of the Borna Disease Virus Nucleoprotein

PDB ID 1n93

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