1q89

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[[Image:1q89.png|left|200px]]
 
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==Crystal structure of the C-domain of the T.vaginalis Inr binding protein, IBP39 (cubic crystal form)==
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The line below this paragraph, containing "STRUCTURE_1q89", creates the "Structure Box" on the page.
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<StructureSection load='1q89' size='340' side='right'caption='[[1q89]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1q89]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trichomonas_vaginalis Trichomonas vaginalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q89 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q89 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q89 OCA], [https://pdbe.org/1q89 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q89 RCSB], [https://www.ebi.ac.uk/pdbsum/1q89 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q89 ProSAT]</span></td></tr>
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{{STRUCTURE_1q89| PDB=1q89 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q95VR4_TRIVA Q95VR4_TRIVA]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q8/1q89_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q89 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Transcription start site selection in eukaryotes is mediated through combinations of the TATA, initiator (Inr), and downstream promoter elements (DPE). In Trichomonas vaginalis, a parabasalian flagellate thought to represent an ancient eukaryote lineage, the Inr appears to be solely responsible for start site selection and is recognized by the initiator binding protein 39 kDa (IBP39). IBP39 contains an N-terminal Inr binding domain (IBD) connected via a flexible linker to a C-terminal domain (C domain). Here we present crystal structures of the apoIBD and IBD-Inr complexes and the C domain. The IBD structures reveal a winged-helix motif with prokaryotic and eukaryotic features and a scaffold similar to that of ETS-family proteins. The C domain structure and biochemical studies indicate that it interacts with the T. vaginalis RNAP II large subunit C-terminal domain. These data suggest that binding of IBP39 to the Inr directly recruits RNAP II and in this way initiates transcription.
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===Crystal structure of the C-domain of the T.vaginalis Inr binding protein, IBP39 (cubic crystal form)===
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Structural basis of core promoter recognition in a primitive eukaryote.,Schumacher MA, Lau AO, Johnson PJ Cell. 2003 Nov 14;115(4):413-24. PMID:14622596<ref>PMID:14622596</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 1q89" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 14622596 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_14622596}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1Q89 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Trichomonas_vaginalis Trichomonas vaginalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q89 OCA].
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==Reference==
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Structural basis of core promoter recognition in a primitive eukaryote., Schumacher MA, Lau AO, Johnson PJ, Cell. 2003 Nov 14;115(4):413-24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14622596 14622596]
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[[Category: Single protein]]
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[[Category: Trichomonas vaginalis]]
[[Category: Trichomonas vaginalis]]
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[[Category: Johnson, P J.]]
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[[Category: Johnson PJ]]
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[[Category: Schumacher, M A.]]
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[[Category: Schumacher MA]]
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[[Category: Core promoter]]
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[[Category: Initator binding protein]]
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[[Category: Inr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:09:47 2008''
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Current revision

Crystal structure of the C-domain of the T.vaginalis Inr binding protein, IBP39 (cubic crystal form)

PDB ID 1q89

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