1qfp

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{{Seed}}
 
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[[Image:1qfp.png|left|200px]]
 
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==N-TERMINAL DOMAIN OF SIALOADHESIN (MOUSE)==
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The line below this paragraph, containing "STRUCTURE_1qfp", creates the "Structure Box" on the page.
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<StructureSection load='1qfp' size='340' side='right'caption='[[1qfp]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1qfp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QFP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QFP FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qfp OCA], [https://pdbe.org/1qfp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qfp RCSB], [https://www.ebi.ac.uk/pdbsum/1qfp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qfp ProSAT]</span></td></tr>
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{{STRUCTURE_1qfp| PDB=1qfp | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SN_MOUSE SN_MOUSE] Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells (By similarity). Preferentially binds to alpha-2,3-linked sialic acid. Binds to SPN/CD43 on T-cells. May play a role in hematopoiesis. May act as a counter-receptor for CLEC10A in lymph node.<ref>PMID:15364954</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qf/1qfp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qfp ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structure of the functional N-terminal domain from the extracellular region of the cell surface receptor sialoadhesin has been determined in complex with the oligosaccharide 3' sialyllactose. This provides structural information for the siglec family of proteins. The structure conforms to the V-set immunoglobulin-like fold but contains several distinctive features, including an intra-beta sheet disulphide and a splitting of the standard beta strand G into two shorter strands. These novel features appear important in adapting the V-set fold for sialic acid-mediated recognition. Analysis of the complex with 3'sialyllactose highlights three residues, conserved throughout the siglec family, as key features of the sialic acid-binding template. The complex is representative of the functional recognition interaction with carbohydrate and as such provides detailed information for a heterotypic cell adhesion interaction.
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===N-TERMINAL DOMAIN OF SIALOADHESIN (MOUSE)===
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Crystal structure of the N-terminal domain of sialoadhesin in complex with 3' sialyllactose at 1.85 A resolution.,May AP, Robinson RC, Vinson M, Crocker PR, Jones EY Mol Cell. 1998 Apr;1(5):719-28. PMID:9660955<ref>PMID:9660955</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_9660955}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1qfp" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 9660955 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_9660955}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1QFP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QFP OCA].
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==Reference==
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Crystal structure of the N-terminal domain of sialoadhesin in complex with 3' sialyllactose at 1.85 A resolution., May AP, Robinson RC, Vinson M, Crocker PR, Jones EY, Mol Cell. 1998 Apr;1(5):719-28. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9660955 9660955]
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Burtnick L]]
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[[Category: Burtnick, L.]]
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[[Category: Crocker PR]]
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[[Category: Crocker, P R.]]
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[[Category: Jones EY]]
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[[Category: Jones, E Y.]]
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[[Category: May AP]]
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[[Category: May, A P.]]
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[[Category: Robinson RC]]
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[[Category: Robinson, R C.]]
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[[Category: Carbohydrate binding]]
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[[Category: Immunoglobulin superfamily]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:11:08 2008''
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Current revision

N-TERMINAL DOMAIN OF SIALOADHESIN (MOUSE)

PDB ID 1qfp

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