1zxv

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{{Seed}}
 
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[[Image:1zxv.png|left|200px]]
 
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==X-Ray Crystal Structure of the Anthrax Lethal Factor Bound to a Small Molecule Inhibitor, BI-MFM3, 3-{5-[5-(4-Chloro-phenyl)-furan-2-ylmethylene]-4-oxo-2-thioxo-thiazolidin-3-yl}-propionic acid.==
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The line below this paragraph, containing "STRUCTURE_1zxv", creates the "Structure Box" on the page.
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<StructureSection load='1zxv' size='340' side='right'caption='[[1zxv]], [[Resolution|resolution]] 2.67&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1zxv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZXV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZXV FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.67&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MFM:(E)-3-(5((5-(4-CHLOROPHENYL)FURAN-2-YL)METHYLENE)-4-OXO-2-THIOXOTHIAZOLIDIN-3-YL)PROPANOIC+ACID'>MFM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1zxv| PDB=1zxv | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zxv OCA], [https://pdbe.org/1zxv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zxv RCSB], [https://www.ebi.ac.uk/pdbsum/1zxv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zxv ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q52NH3_BACAN Q52NH3_BACAN]
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===X-Ray Crystal Structure of the Anthrax Lethal Factor Bound to a Small Molecule Inhibitor, BI-MFM3, 3-{5-[5-(4-Chloro-phenyl)-furan-2-ylmethylene]-4-oxo-2-thioxo-thiazolidin-3-yl}-propionic acid.===
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==See Also==
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*[[Anthrax lethal factor 3D structures|Anthrax lethal factor 3D structures]]
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__TOC__
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 15983377 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15983377}}
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==About this Structure==
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1ZXV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZXV OCA].
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==Reference==
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Efficient synthetic inhibitors of anthrax lethal factor., Forino M, Johnson S, Wong TY, Rozanov DV, Savinov AY, Li W, Fattorusso R, Becattini B, Orry AJ, Jung D, Abagyan RA, Smith JW, Alibek K, Liddington RC, Strongin AY, Pellecchia M, Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9499-504. Epub 2005 Jun 27. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15983377 15983377]
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[[Category: Anthrax lethal factor endopeptidase]]
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[[Category: Bacillus anthracis]]
[[Category: Bacillus anthracis]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Liddington, R C.]]
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[[Category: Liddington RC]]
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[[Category: Wong, T Y.]]
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[[Category: Wong TY]]
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[[Category: Anthrax toxin lethal factor]]
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[[Category: Protein and small molecule inhibitor complex]]
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[[Category: Zinc metalloproteinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:23:32 2008''
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Current revision

X-Ray Crystal Structure of the Anthrax Lethal Factor Bound to a Small Molecule Inhibitor, BI-MFM3, 3-{5-[5-(4-Chloro-phenyl)-furan-2-ylmethylene]-4-oxo-2-thioxo-thiazolidin-3-yl}-propionic acid.

PDB ID 1zxv

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