1sna

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[[Image:1sna.png|left|200px]]
 
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==An Oligomeric Domain-Swapped Beta-Beta-Alpha Mini-Protein==
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The line below this paragraph, containing "STRUCTURE_1sna", creates the "Structure Box" on the page.
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<StructureSection load='1sna' size='340' side='right'caption='[[1sna]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1sna]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SNA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SNA FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DBZ:3-(BENZOYLAMINO)-L-ALANINE'>DBZ</scene>, <scene name='pdbligand=DPR:D-PROLINE'>DPR</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=MSO:SELENOMETHIONINE+SELENOXIDE'>MSO</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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{{STRUCTURE_1sna| PDB=1sna | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sna OCA], [https://pdbe.org/1sna PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sna RCSB], [https://www.ebi.ac.uk/pdbsum/1sna PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sna ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The x-ray crystal structure of an oligomeric miniprotein has been determined to a 1.2-A resolution by means of multiwavelength anomalous diffraction phasing with selenomethionine analogs that retain the biophysical characteristics of the native peptide. Peptide 1, comprising alpha and beta secondary structure elements with only 21 aa per monomer, associates as a discrete tetramer. The peptide adopts a previously uncharacterized quaternary structure in which alpha and beta components interact to form a tightly packed and well defined hydrophobic core. The structure provides insight into the origins of the unusual thermal stability of the oligomer. The miniprotein shares many characteristics of larger proteins, including cooperative folding, lack of 1-anilino-8-naphthalene sulfonate binding, and limited deuterium exchange, and possesses a buried surface area typical of native proteins.
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===An Oligomeric Domain-Swapped Beta-Beta-Alpha Mini-Protein===
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X-ray structure analysis of a designed oligomeric miniprotein reveals a discrete quaternary architecture.,Ali MH, Peisach E, Allen KN, Imperiali B Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12183-8. Epub 2004 Aug 9. PMID:15302930<ref>PMID:15302930</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 1sna" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15302930 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15302930}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SNA OCA].
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[[Category: Ali MH]]
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[[Category: Allen KN]]
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==Reference==
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[[Category: Imperiali B]]
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X-ray structure analysis of a designed oligomeric miniprotein reveals a discrete quaternary architecture., Ali MH, Peisach E, Allen KN, Imperiali B, Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12183-8. Epub 2004 Aug 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15302930 15302930]
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[[Category: Peisach E]]
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[[Category: Ali, M H.]]
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[[Category: Allen, K N.]]
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[[Category: Imperiali, B.]]
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[[Category: Peisach, E.]]
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[[Category: Domain swapping]]
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[[Category: Mini-protein]]
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[[Category: Oligomerization]]
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[[Category: Protein design]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:24:45 2008''
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Current revision

An Oligomeric Domain-Swapped Beta-Beta-Alpha Mini-Protein

PDB ID 1sna

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