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1hw4

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{{Seed}}
 
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[[Image:1hw4.png|left|200px]]
 
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==STRUCTURE OF THYMIDYLATE SYNTHASE SUGGESTS ADVANTAGES OF CHEMOTHERAPY WITH NONCOMPETITIVE INHIBITORS==
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The line below this paragraph, containing "STRUCTURE_1hw4", creates the "Structure Box" on the page.
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<StructureSection load='1hw4' size='340' side='right'caption='[[1hw4]], [[Resolution|resolution]] 2.06&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1hw4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HW4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HW4 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.06&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1hw4| PDB=1hw4 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hw4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hw4 OCA], [https://pdbe.org/1hw4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hw4 RCSB], [https://www.ebi.ac.uk/pdbsum/1hw4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hw4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TYSY_HUMAN TYSY_HUMAN] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.<ref>PMID:21876188</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hw/1hw4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hw4 ConSurf].
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<div style="clear:both"></div>
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===STRUCTURE OF THYMIDYLATE SYNTHASE SUGGESTS ADVANTAGES OF CHEMOTHERAPY WITH NONCOMPETITIVE INHIBITORS===
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==See Also==
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*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_11278511}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 11278511 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_11278511}}
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==About this Structure==
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1HW4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HW4 OCA].
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==Reference==
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Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors., Phan J, Steadman DJ, Koli S, Ding WC, Minor W, Dunlap RB, Berger SH, Lebioda L, J Biol Chem. 2001 Apr 27;276(17):14170-7. Epub 2001 Jan 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11278511 11278511]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Thymidylate synthase]]
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[[Category: Berger SH]]
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[[Category: Berger, S H.]]
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[[Category: Ding WC]]
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[[Category: Ding, W C.]]
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[[Category: Dunlap RB]]
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[[Category: Dunlap, R B.]]
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[[Category: Koli S]]
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[[Category: Koli, S.]]
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[[Category: Lebioda L]]
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[[Category: Lebioda, L.]]
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[[Category: Minor W]]
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[[Category: Minor, W.]]
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[[Category: Phan J]]
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[[Category: Phan, J.]]
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[[Category: Steadman JD]]
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[[Category: Steadman, J D.]]
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[[Category: Methyltransferase]]
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[[Category: Thymidylate synthase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:25:58 2008''
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Current revision

STRUCTURE OF THYMIDYLATE SYNTHASE SUGGESTS ADVANTAGES OF CHEMOTHERAPY WITH NONCOMPETITIVE INHIBITORS

PDB ID 1hw4

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