2v9a

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{{Seed}}
 
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[[Image:2v9a.png|left|200px]]
 
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==Structure of Citrate-free Periplasmic Domain of Sensor Histidine Kinase CitA==
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The line below this paragraph, containing "STRUCTURE_2v9a", creates the "Structure Box" on the page.
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<StructureSection load='2v9a' size='340' side='right'caption='[[2v9a]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2v9a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V9A FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v9a OCA], [https://pdbe.org/2v9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v9a RCSB], [https://www.ebi.ac.uk/pdbsum/2v9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v9a ProSAT]</span></td></tr>
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{{STRUCTURE_2v9a| PDB=2v9a | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CITA_KLEPN CITA_KLEPN] Member of the two-component regulatory system CitA/CitB. Probably activates CitB by phosphorylation. The periplasmic domain binds H-citrate(2-), which is essential for induction of the citrate-fermentation genes.<ref>PMID:10447894</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v9/2v9a_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v9a ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Sensor histidine kinases of two-component signal-transduction systems are essential for bacteria to adapt to variable environmental conditions. However, despite their prevalence, it is not well understood how extracellular signals such as ligand binding regulate the activity of these sensor kinases. CitA is the sensor histidine kinase in Klebsiella pneumoniae that regulates the transport and anaerobic metabolism of citrate in response to its extracellular concentration. We report here the X-ray structures of the periplasmic sensor domain of CitA in the citrate-free and citrate-bound states. A comparison of the two structures shows that ligand binding causes a considerable contraction of the sensor domain. This contraction may represent the molecular switch that activates transmembrane signaling in the receptor.
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===STRUCTURE OF CITRATE-FREE PERIPLASMIC DOMAIN OF SENSOR HISTIDINE KINASE CITA===
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A ligand-induced switch in the periplasmic domain of sensor histidine kinase CitA.,Sevvana M, Vijayan V, Zweckstetter M, Reinelt S, Madden DR, Herbst-Irmer R, Sheldrick GM, Bott M, Griesinger C, Becker S J Mol Biol. 2008 Mar 21;377(2):512-23. Epub 2008 Jan 16. PMID:18258261<ref>PMID:18258261</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_18258261}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2v9a" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 18258261 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18258261}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2V9A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V9A OCA].
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==Reference==
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A ligand-induced switch in the periplasmic domain of sensor histidine kinase CitA., Sevvana M, Vijayan V, Zweckstetter M, Reinelt S, Madden DR, Herbst-Irmer R, Sheldrick GM, Bott M, Griesinger C, Becker S, J Mol Biol. 2008 Mar 21;377(2):512-23. Epub 2008 Jan 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18258261 18258261]
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[[Category: Histidine kinase]]
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[[Category: Klebsiella pneumoniae]]
[[Category: Klebsiella pneumoniae]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Becker, S.]]
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[[Category: Becker S]]
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[[Category: Bott, M.]]
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[[Category: Bott M]]
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[[Category: Griesinger, C.]]
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[[Category: Griesinger C]]
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[[Category: Madden, D R.]]
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[[Category: Madden DR]]
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[[Category: Reinelt, S.]]
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[[Category: Reinelt S]]
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[[Category: Sevvana, M.]]
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[[Category: Sevvana M]]
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[[Category: Sheldrick, G M.]]
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[[Category: Sheldrick GM]]
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[[Category: Vijayan, V.]]
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[[Category: Vijayan V]]
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[[Category: Zweckstetter, M.]]
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[[Category: Zweckstetter M]]
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[[Category: Cita]]
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[[Category: Inner membrane]]
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[[Category: Kinase]]
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[[Category: Membrane]]
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[[Category: Phosphorylation]]
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[[Category: Sensor domain]]
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[[Category: Sensor histidine kinase]]
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[[Category: Signal transduction]]
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[[Category: Transferase]]
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[[Category: Transmembrane]]
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[[Category: Two-component regulatory system]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:25:57 2008''
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Current revision

Structure of Citrate-free Periplasmic Domain of Sensor Histidine Kinase CitA

PDB ID 2v9a

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