2gnb

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{{Seed}}
 
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[[Image:2gnb.png|left|200px]]
 
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==EDTA-treated (2 weeks) P. angolensis lectin==
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The line below this paragraph, containing "STRUCTURE_2gnb", creates the "Structure Box" on the page.
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<StructureSection load='2gnb' size='340' side='right'caption='[[2gnb]], [[Resolution|resolution]] 2.27&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2gnb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pterocarpus_angolensis Pterocarpus angolensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GNB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GNB FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
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{{STRUCTURE_2gnb| PDB=2gnb | SCENE= }}
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ukg|1ukg]], [[2gme|2gme]], [[2gmm|2gmm]], [[2gmp|2gmp]], [[2gn3|2gn3]]</div></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gnb OCA], [https://pdbe.org/2gnb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gnb RCSB], [https://www.ebi.ac.uk/pdbsum/2gnb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gnb ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gn/2gnb_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gnb ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The interplay between metal binding, carbohydrate binding activity, stability and structure of the lectin from Pterocarpus angolensis was investigated. Removal of the metals leads to a more flexible form of the protein with significantly less conformational stability. Crystal structures of this metal-free form show significant structural rearrangements, although some structural features that allow the binding of sugars are retained. We propose that substitution of an asparagine residue at the start of the C-terminal beta-strand of the legume lectin monomer hinders the trans-isomerization of the cis-peptide bond upon demetallization and constitutes an intramolecular switch governing the isomer state of the non-proline bond and ultimately the lectin phenotype.
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===EDTA-treated (2 weeks) P. angolensis lectin===
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Interplay between metal binding and cis/trans isomerization in legume lectins: structural and thermodynamic study of P. angolensis lectin.,Garcia-Pino A, Buts L, Wyns L, Loris R J Mol Biol. 2006 Aug 4;361(1):153-67. Epub 2006 Jun 21. PMID:16824540<ref>PMID:16824540</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_16824540}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2gnb" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16824540 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16824540}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2GNB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pterocarpus_angolensis Pterocarpus angolensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GNB OCA].
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==Reference==
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Interplay between metal binding and cis/trans isomerization in legume lectins: structural and thermodynamic study of P. angolensis lectin., Garcia-Pino A, Buts L, Wyns L, Loris R, J Mol Biol. 2006 Aug 4;361(1):153-67. Epub 2006 Jun 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16824540 16824540]
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[[Category: Pterocarpus angolensis]]
[[Category: Pterocarpus angolensis]]
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[[Category: Single protein]]
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[[Category: Buts, L]]
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[[Category: Buts, L.]]
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[[Category: Garcia-Pino, A]]
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[[Category: Garcia-Pino, A.]]
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[[Category: Loris, R]]
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[[Category: Loris, R.]]
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[[Category: Wyns, L]]
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[[Category: Wyns, L.]]
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[[Category: Beta sandwich]]
[[Category: Beta sandwich]]
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[[Category: Edta treatment]]
[[Category: Legume lectin]]
[[Category: Legume lectin]]
[[Category: Mannose]]
[[Category: Mannose]]
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[[Category: Metal-free lectin,edta treatment]]
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[[Category: Metal-free lectin]]
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[[Category: Sugar binding protein]]
[[Category: Sugar complex]]
[[Category: Sugar complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:34:10 2008''
 

Current revision

EDTA-treated (2 weeks) P. angolensis lectin

PDB ID 2gnb

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