1rsi

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{{Seed}}
 
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[[Image:1rsi.png|left|200px]]
 
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==DHNA complex with 2-Amino-5-bromo-3-hydroxy-6-phenylpyrimidine==
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The line below this paragraph, containing "STRUCTURE_1rsi", creates the "Structure Box" on the page.
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<StructureSection load='1rsi' size='340' side='right'caption='[[1rsi]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1rsi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RSI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RSI FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=977:2-AMINO-5-BROMO-6-PHENYLPYRIMIDIN-4-OL'>977</scene></td></tr>
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{{STRUCTURE_1rsi| PDB=1rsi | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rsi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rsi OCA], [https://pdbe.org/1rsi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rsi RCSB], [https://www.ebi.ac.uk/pdbsum/1rsi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rsi ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FOLB_STAAU FOLB_STAAU] Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rs/1rsi_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rsi ConSurf].
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<div style="clear:both"></div>
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===DHNA complex with 2-Amino-5-bromo-3-hydroxy-6-phenylpyrimidine===
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==See Also==
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*[[Aldolase 3D structures|Aldolase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_15027862}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 15027862 is the PubMed ID number.
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-->
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{{ABSTRACT_PUBMED_15027862}}
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==About this Structure==
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1RSI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RSI OCA].
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==Reference==
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Discovery of potent inhibitors of dihydroneopterin aldolase using CrystaLEAD high-throughput X-ray crystallographic screening and structure-directed lead optimization., Sanders WJ, Nienaber VL, Lerner CG, McCall JO, Merrick SM, Swanson SJ, Harlan JE, Stoll VS, Stamper GF, Betz SF, Condroski KR, Meadows RP, Severin JM, Walter KA, Magdalinos P, Jakob CG, Wagner R, Beutel BA, J Med Chem. 2004 Mar 25;47(7):1709-18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15027862 15027862]
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[[Category: Dihydroneopterin aldolase]]
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[[Category: Single protein]]
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[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
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[[Category: Betz, S F.]]
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[[Category: Betz SF]]
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[[Category: Beutel, B A.]]
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[[Category: Beutel BA]]
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[[Category: Condroski, K R.]]
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[[Category: Condroski KR]]
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[[Category: Harlan, J E.]]
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[[Category: Harlan JE]]
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[[Category: Jakob, C G.]]
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[[Category: Jakob CG]]
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[[Category: Lerner, C G.]]
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[[Category: Lerner CG]]
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[[Category: Magdalinos, P.]]
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[[Category: Magdalinos P]]
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[[Category: McCall, J O.]]
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[[Category: McCall JO]]
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[[Category: Meadows, R P.]]
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[[Category: Meadows RP]]
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[[Category: Merrick, S M.]]
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[[Category: Merrick SM]]
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[[Category: Nienaber, V L.]]
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[[Category: Nienaber VL]]
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[[Category: Sanders, W J.]]
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[[Category: Sanders WJ]]
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[[Category: Severin, J M.]]
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[[Category: Severin JM]]
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[[Category: Stamper, G F.]]
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[[Category: Stamper GF]]
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[[Category: Stoll, V S.]]
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[[Category: Stoll VS]]
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[[Category: Swanson, S J.]]
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[[Category: Swanson SJ]]
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[[Category: Wagner, R.]]
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[[Category: Wagner R]]
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[[Category: Walter, K A.]]
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[[Category: Walter KA]]
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[[Category: 2-amino-5-bromo-3-hydroxy-6-phenylpyrimidine]]
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[[Category: 7,8-dihydroneopterin aldolase]]
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[[Category: Dhna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:40:43 2008''
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Current revision

DHNA complex with 2-Amino-5-bromo-3-hydroxy-6-phenylpyrimidine

PDB ID 1rsi

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