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3bgd

From Proteopedia

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{{Seed}}
 
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[[Image:3bgd.png|left|200px]]
 
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<!--
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==Thiopurine S-Methyltransferase==
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The line below this paragraph, containing "STRUCTURE_3bgd", creates the "Structure Box" on the page.
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<StructureSection load='3bgd' size='340' side='right'caption='[[3bgd]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3bgd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BGD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BGD FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PM6:9H-PURINE-6-THIOL'>PM6</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
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{{STRUCTURE_3bgd| PDB=3bgd | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bgd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bgd OCA], [https://pdbe.org/3bgd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bgd RCSB], [https://www.ebi.ac.uk/pdbsum/3bgd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bgd ProSAT]</span></td></tr>
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</table>
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===Thiopurine S-Methyltransferase===
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== Function ==
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[https://www.uniprot.org/uniprot/TPMT_MOUSE TPMT_MOUSE] Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_18484748}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 18484748 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bg/3bgd_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_18484748}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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3BGD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BGD OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bgd ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Structural basis of substrate recognition in thiopurine s-methyltransferase., Peng Y, Feng Q, Wilk D, Adjei AA, Salavaggione OE, Weinshilboum RM, Yee VC, Biochemistry. 2008 Jun 10;47(23):6216-25. Epub 2008 May 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18484748 18484748]
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Peng Y]]
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[[Category: Thiopurine S-methyltransferase]]
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[[Category: Yee VC]]
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[[Category: Peng, Y.]]
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[[Category: Yee, V C.]]
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[[Category: Cytoplasm]]
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[[Category: Methyltransferase]]
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[[Category: S-adenosyl-l-methionine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:42:24 2008''
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Current revision

Thiopurine S-Methyltransferase

PDB ID 3bgd

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