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1p0z

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{{Seed}}
 
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[[Image:1p0z.png|left|200px]]
 
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<!--
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==Sensor Kinase CitA binding domain==
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The line below this paragraph, containing "STRUCTURE_1p0z", creates the "Structure Box" on the page.
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<StructureSection load='1p0z' size='340' side='right'caption='[[1p0z]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1p0z]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P0Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P0Z FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=MO7:BIS(MU4-OXO)-BIS(MU3-OXO)-OCTAKIS(MU2-OXO)-DODECAOXO-HEPTAMOLYBDENUM+(VI)'>MO7</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OMO:MO(VI)(=O)(OH)2+CLUSTER'>OMO</scene></td></tr>
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{{STRUCTURE_1p0z| PDB=1p0z | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p0z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p0z OCA], [https://pdbe.org/1p0z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p0z RCSB], [https://www.ebi.ac.uk/pdbsum/1p0z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p0z ProSAT]</span></td></tr>
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</table>
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===Sensor Kinase CitA binding domain===
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== Function ==
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[https://www.uniprot.org/uniprot/CITA_KLEPN CITA_KLEPN] Member of the two-component regulatory system CitA/CitB. Probably activates CitB by phosphorylation. The periplasmic domain binds H-citrate(2-), which is essential for induction of the citrate-fermentation genes.<ref>PMID:10447894</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_12867417}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 12867417 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p0/1p0z_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_12867417}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1P0Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P0Z OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1p0z ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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The structure of the periplasmic ligand-binding domain of the sensor kinase CitA reveals the first extracellular PAS domain., Reinelt S, Hofmann E, Gerharz T, Bott M, Madden DR, J Biol Chem. 2003 Oct 3;278(40):39189-96. Epub 2003 Jul 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12867417 12867417]
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<references/>
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[[Category: Histidine kinase]]
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__TOC__
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</StructureSection>
[[Category: Klebsiella pneumoniae]]
[[Category: Klebsiella pneumoniae]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bott, M.]]
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[[Category: Bott M]]
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[[Category: Gerharz, T.]]
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[[Category: Gerharz T]]
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[[Category: Hofmann, E.]]
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[[Category: Hofmann E]]
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[[Category: Madden, D R.]]
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[[Category: Madden DR]]
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[[Category: Reinelt, S.]]
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[[Category: Reinelt S]]
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[[Category: Kinase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:10:17 2008''
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Current revision

Sensor Kinase CitA binding domain

PDB ID 1p0z

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