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1nhz

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{{Seed}}
 
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[[Image:1nhz.png|left|200px]]
 
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==Crystal Structure of the Antagonist Form of Glucocorticoid Receptor==
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The line below this paragraph, containing "STRUCTURE_1nhz", creates the "Structure Box" on the page.
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<StructureSection load='1nhz' size='340' side='right'caption='[[1nhz]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1nhz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NHZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NHZ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=486:11-(4-DIMETHYLAMINO-PHENYL)-17-HYDROXY-13-METHYL-17-PROP-1-YNYL-1,2,6,7,8,11,12,13,14,15,16,17-DODEC+AHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE'>486</scene>, <scene name='pdbligand=HEZ:HEXANE-1,6-DIOL'>HEZ</scene></td></tr>
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{{STRUCTURE_1nhz| PDB=1nhz | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nhz OCA], [https://pdbe.org/1nhz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nhz RCSB], [https://www.ebi.ac.uk/pdbsum/1nhz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nhz ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN] Defects in NR3C1 are a cause of glucocorticoid resistance (GCRES) [MIM:[https://omim.org/entry/138040 138040]; also known as cortisol resistance. It is a hypertensive, hyperandrogenic disorder characterized by increased serum cortisol concentrations. Inheritance is autosomal dominant.<ref>PMID:12050230</ref> <ref>PMID:1704018</ref> <ref>PMID:7683692</ref> <ref>PMID:11589680</ref> <ref>PMID:11701741</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN] Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation.<ref>PMID:21664385</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nh/1nhz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nhz ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of the Antagonist Form of Glucocorticoid Receptor===
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==See Also==
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*[[Glucocorticoid receptor 3D structures|Glucocorticoid receptor 3D structures]]
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== References ==
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<!--
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_12686538}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 12686538 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_12686538}}
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==About this Structure==
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1NHZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NHZ OCA].
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==Reference==
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The three-dimensional structures of antagonistic and agonistic forms of the glucocorticoid receptor ligand-binding domain: RU-486 induces a transconformation that leads to active antagonism., Kauppi B, Jakob C, Farnegardh M, Yang J, Ahola H, Alarcon M, Calles K, Engstrom O, Harlan J, Muchmore S, Ramqvist AK, Thorell S, Ohman L, Greer J, Gustafsson JA, Carlstedt-Duke J, Carlquist M, J Biol Chem. 2003 Jun 20;278(25):22748-54. Epub 2003 Apr 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12686538 12686538]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Ahola, H.]]
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[[Category: Ahola H]]
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[[Category: Alarcon, M.]]
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[[Category: Alarcon M]]
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[[Category: Calles, K.]]
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[[Category: Calles K]]
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[[Category: Carlquist, M.]]
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[[Category: Carlquist M]]
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[[Category: Carlstedt-Duke, J.]]
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[[Category: Carlstedt-Duke J]]
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[[Category: Engstrom, O.]]
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[[Category: Engstrom O]]
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[[Category: Farnegardh, M.]]
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[[Category: Farnegardh M]]
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[[Category: Greer, J.]]
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[[Category: Greer J]]
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[[Category: Gustafsson, J A.]]
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[[Category: Gustafsson J-A]]
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[[Category: Harlan, J.]]
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[[Category: Harlan J]]
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[[Category: Jakob, C.]]
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[[Category: Jakob C]]
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[[Category: Kauppi, B.]]
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[[Category: Kauppi B]]
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[[Category: Muchmore, S.]]
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[[Category: Muchmore S]]
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[[Category: Ohman, L.]]
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[[Category: Ohman L]]
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[[Category: Ramqvist, A K.]]
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[[Category: Ramqvist A-K]]
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[[Category: Thorell, S.]]
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[[Category: Thorell S]]
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[[Category: Yang, J.]]
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[[Category: Yang J]]
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[[Category: Anti parallel alpha helix sandwich]]
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[[Category: Protien-ligand complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:17:50 2008''
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Current revision

Crystal Structure of the Antagonist Form of Glucocorticoid Receptor

PDB ID 1nhz

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