1prv

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{{Seed}}
 
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[[Image:1prv.png|left|200px]]
 
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==PURINE REPRESSOR DNA-BINDING DOMAIN DNA BINDING==
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The line below this paragraph, containing "STRUCTURE_1prv", creates the "Structure Box" on the page.
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<StructureSection load='1prv' size='340' side='right'caption='[[1prv]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1prv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PRV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PRV FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1prv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1prv OCA], [https://pdbe.org/1prv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1prv RCSB], [https://www.ebi.ac.uk/pdbsum/1prv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1prv ProSAT]</span></td></tr>
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{{STRUCTURE_1prv| PDB=1prv | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PURR_ECOLI PURR_ECOLI] Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. In addition, it participates in the regulation or coregulation of genes involved in de novo pyrimidine nucleotide biosynthesis, salvage and uptake (pyrC, pyrD, carAB and codBA), and of several genes encoding enzymes necessary for nucleotide and polyamine biosynthesis (prsA, glyA, gcvTHP, speA, glnB). Binds to a 16-bp palindromic sequence located within the promoter region of pur regulon genes. The consensus binding sequence is 5'-ACGCAAACGTTTTCNT-3'. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression.<ref>PMID:2404765</ref> <ref>PMID:2211500</ref> <ref>PMID:1400170</ref> <ref>PMID:14741201</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pr/1prv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1prv ConSurf].
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<div style="clear:both"></div>
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===PURINE REPRESSOR DNA-BINDING DOMAIN DNA BINDING===
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==See Also==
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*[[Purine repressor|Purine repressor]]
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== References ==
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 8591032 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_8591032}}
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==About this Structure==
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1PRV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PRV OCA].
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==Reference==
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Structural comparison of the free and DNA-bound forms of the purine repressor DNA-binding domain., Nagadoi A, Morikawa S, Nakamura H, Enari M, Kobayashi K, Yamamoto H, Sampei G, Mizobuchi K, Schumacher MA, Brennan RG, et al., Structure. 1995 Nov 15;3(11):1217-24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8591032 8591032]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Brennan, R G.]]
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[[Category: Brennan RG]]
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[[Category: Enari, M.]]
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[[Category: Enari M]]
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[[Category: Kobayashi, K.]]
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[[Category: Kobayashi K]]
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[[Category: Mizobuchi, K.]]
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[[Category: Mizobuchi K]]
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[[Category: Morikawa, S.]]
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[[Category: Morikawa S]]
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[[Category: Nagadoi, A.]]
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[[Category: Nagadoi A]]
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[[Category: Nakamura, H.]]
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[[Category: Nakamura H]]
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[[Category: Nishimura, Y.]]
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[[Category: Nishimura Y]]
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[[Category: Sampei, G.]]
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[[Category: Sampei G]]
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[[Category: Schumacher, M A.]]
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[[Category: Schumacher MA]]
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[[Category: Yamamoto, H.]]
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[[Category: Yamamoto H]]
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[[Category: Purine repressor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:19:05 2008''
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Current revision

PURINE REPRESSOR DNA-BINDING DOMAIN DNA BINDING

PDB ID 1prv

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