2p9r

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{{Seed}}
 
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[[Image:2p9r.png|left|200px]]
 
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==Human alpha2-macroglogulin is composed of multiple domains, as predicted by homology with complement component C3==
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The line below this paragraph, containing "STRUCTURE_2p9r", creates the "Structure Box" on the page.
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<StructureSection load='2p9r' size='340' side='right'caption='[[2p9r]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2p9r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P9R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P9R FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p9r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p9r OCA], [https://pdbe.org/2p9r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p9r RCSB], [https://www.ebi.ac.uk/pdbsum/2p9r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p9r ProSAT]</span></td></tr>
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{{STRUCTURE_2p9r| PDB=2p9r | SCENE= }}
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</table>
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== Function ==
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===Human alpha2-macroglogulin is composed of multiple domains, as predicted by homology with complement component C3===
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[https://www.uniprot.org/uniprot/A2MG_HUMAN A2MG_HUMAN] Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_17608619}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 17608619 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p9/2p9r_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_17608619}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Disease==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p9r ConSurf].
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Known disease associated with this structure: Emphysema due to alpha-2-macroglobulin deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=103950 103950]], Alzheimer disease, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=103950 103950]]
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<div style="clear:both"></div>
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__TOC__
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==About this Structure==
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</StructureSection>
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2P9R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P9R OCA].
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==Reference==
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Human alpha2-macroglobulin is composed of multiple domains, as predicted by homology with complement component C3., Doan N, Gettins PG, Biochem J. 2007 Oct 1;407(1):23-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17608619 17608619]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Doan, N.]]
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[[Category: Doan N]]
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[[Category: Human alpha2-macroglobulin]]
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[[Category: Mg2 domain]]
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[[Category: Signaling protein]]
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[[Category: X-ray]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:20:49 2008''
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Current revision

Human alpha2-macroglogulin is composed of multiple domains, as predicted by homology with complement component C3

PDB ID 2p9r

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