3c98

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[[Image:3c98.png|left|200px]]
 
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==Revised structure of the munc18a-syntaxin1 complex==
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The line below this paragraph, containing "STRUCTURE_3c98", creates the "Structure Box" on the page.
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<StructureSection load='3c98' size='340' side='right'caption='[[3c98]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3c98]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1dn1 1dn1]. The November 2013 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''SNARE Proteins'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2013_11 10.2210/rcsb_pdb/mom_2013_11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C98 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C98 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.601&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c98 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c98 OCA], [https://pdbe.org/3c98 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c98 RCSB], [https://www.ebi.ac.uk/pdbsum/3c98 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c98 ProSAT]</span></td></tr>
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{{STRUCTURE_3c98| PDB=3c98 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/STXB1_RAT STXB1_RAT] May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c9/3c98_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c98 ConSurf].
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<div style="clear:both"></div>
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===Revised structure of the munc18a-syntaxin1 complex===
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==See Also==
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*[[Syntaxin 3D structures|Syntaxin 3D structures]]
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*[[Syntaxin-binding protein|Syntaxin-binding protein]]
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__TOC__
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The line below this paragraph, {{ABSTRACT_PUBMED_18337752}}, adds the Publication Abstract to the page
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 18337752 is the PubMed ID number.
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[[Category: Large Structures]]
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[[Category: RCSB PDB Molecule of the Month]]
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{{ABSTRACT_PUBMED_18337752}}
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==About this Structure==
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3C98 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1dn1 1dn1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C98 OCA].
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==Reference==
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Munc18a controls SNARE assembly through its interaction with the syntaxin N-peptide., Burkhardt P, Hattendorf DA, Weis WI, Fasshauer D, EMBO J. 2008 Mar 13;. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18337752 18337752]
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Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex., Misura KM, Scheller RH, Weis WI, Nature. 2000 Mar 23;404(6776):355-62. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10746715 10746715]
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[[Category: Protein complex]]
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Burkhardt, P.]]
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[[Category: SNARE Proteins]]
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[[Category: Fasshauer, D.]]
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[[Category: Burkhardt P]]
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[[Category: Hattendorf, D A.]]
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[[Category: Fasshauer D]]
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[[Category: Misura, K M.]]
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[[Category: Hattendorf DA]]
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[[Category: Scheller, R H.]]
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[[Category: Misura KM]]
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[[Category: Weis, W I.]]
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[[Category: Scheller RH]]
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[[Category: Alternative splicing]]
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[[Category: Weis WI]]
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[[Category: Coiled coil]]
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[[Category: Cytoplasm]]
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[[Category: Endocytosis/exocytosis complex]]
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[[Category: Membrane]]
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[[Category: Neurotransmitter transport]]
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[[Category: Phosphoprotein]]
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[[Category: Protein complex]]
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[[Category: Protein transport]]
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[[Category: Transmembrane]]
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[[Category: Transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:22:39 2008''
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Current revision

Revised structure of the munc18a-syntaxin1 complex

PDB ID 3c98

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