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1rqr

From Proteopedia

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{{Seed}}
 
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[[Image:1rqr.png|left|200px]]
 
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<!--
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==Crystal structure and mechanism of a bacterial fluorinating enzyme, product complex==
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The line below this paragraph, containing "STRUCTURE_1rqr", creates the "Structure Box" on the page.
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<StructureSection load='1rqr' size='340' side='right'caption='[[1rqr]], [[Resolution|resolution]] 2.67&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1rqr]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_cattleya Streptomyces cattleya]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RQR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RQR FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.67&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5FD:5-FLUORO-5-DEOXYADENOSINE'>5FD</scene>, <scene name='pdbligand=MET:METHIONINE'>MET</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_1rqr| PDB=1rqr | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rqr OCA], [https://pdbe.org/1rqr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rqr RCSB], [https://www.ebi.ac.uk/pdbsum/1rqr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rqr ProSAT]</span></td></tr>
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</table>
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===Crystal structure and mechanism of a bacterial fluorinating enzyme, product complex===
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== Function ==
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[https://www.uniprot.org/uniprot/FLA_STRCT FLA_STRCT] Involved in the biosynthesis of fluorometabolites. Catalyzes the formation of a C-F bond by combining S-adenosyl-L-methionine (SAM) and fluoride to generate 5'-fluoro-5'-deoxyadenosine (5'-FDA) and L-methionine. It can also use 2'-deoxyadenosine in place of adenosine as substrate.<ref>PMID:12860396</ref> <ref>PMID:14765200</ref> <ref>PMID:16370017</ref> <ref>PMID:16604208</ref> <ref>PMID:16720268</ref> <ref>PMID:17985882</ref>
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== Evolutionary Conservation ==
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<!--
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_14765200}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 14765200 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rq/1rqr_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_14765200}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1RQR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_cattleya Streptomyces cattleya]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RQR OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rqr ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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Crystal structure and mechanism of a bacterial fluorinating enzyme., Dong C, Huang F, Deng H, Schaffrath C, Spencer JB, O'Hagan D, Naismith JH, Nature. 2004 Feb 5;427(6974):561-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14765200 14765200]
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<references/>
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[[Category: Adenosyl-fluoride synthase]]
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__TOC__
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[[Category: Single protein]]
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Streptomyces cattleya]]
[[Category: Streptomyces cattleya]]
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[[Category: Deng, H.]]
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[[Category: Deng H]]
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[[Category: Dong, C.]]
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[[Category: Dong C]]
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[[Category: Hagan, D O.]]
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[[Category: Huang F]]
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[[Category: Huang, F.]]
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[[Category: Naismith JH]]
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[[Category: Naismith, J H.]]
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[[Category: O'Hagan D]]
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[[Category: Schaffrath, C.]]
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[[Category: Schaffrath C]]
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[[Category: Spencer, J B.]]
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[[Category: Spencer JB]]
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[[Category: Anti-parallel beta sheet]]
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[[Category: Central 7 stranded beta sheet]]
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[[Category: Fluorinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:28:52 2008''
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Current revision

Crystal structure and mechanism of a bacterial fluorinating enzyme, product complex

PDB ID 1rqr

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