1rv7

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{{Seed}}
 
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[[Image:1rv7.png|left|200px]]
 
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==Crystal structures of a Multidrug-Resistant HIV-1 Protease Reveal an Expanded Active Site Cavity==
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The line below this paragraph, containing "STRUCTURE_1rv7", creates the "Structure Box" on the page.
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<StructureSection load='1rv7' size='340' side='right'caption='[[1rv7]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1rv7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RV7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RV7 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AB1:N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE'>AB1</scene></td></tr>
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{{STRUCTURE_1rv7| PDB=1rv7 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rv7 OCA], [https://pdbe.org/1rv7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rv7 RCSB], [https://www.ebi.ac.uk/pdbsum/1rv7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rv7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9QM22_9HIV1 Q9QM22_9HIV1]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rv/1rv7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rv7 ConSurf].
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<div style="clear:both"></div>
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===Crystal structures of a Multidrug-Resistant HIV-1 Protease Reveal an Expanded Active Site Cavity===
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==See Also==
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*[[Immunodeficiency virus protease 3D structures|Immunodeficiency virus protease 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_14990731}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14990731 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14990731}}
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==About this Structure==
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1RV7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RV7 OCA].
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==Reference==
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Crystal structures of a multidrug-resistant human immunodeficiency virus type 1 protease reveal an expanded active-site cavity., Logsdon BC, Vickrey JF, Martin P, Proteasa G, Koepke JI, Terlecky SR, Wawrzak Z, Winters MA, Merigan TC, Kovari LC, J Virol. 2004 Mar;78(6):3123-32. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14990731 14990731]
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[[Category: HIV-1 retropepsin]]
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[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Koepke, J I.]]
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[[Category: Koepke JI]]
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[[Category: Kovari, L C.]]
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[[Category: Kovari LC]]
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[[Category: Logsdon, B C.]]
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[[Category: Logsdon BC]]
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[[Category: Martin, P.]]
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[[Category: Martin P]]
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[[Category: Merigan, T C.]]
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[[Category: Merigan TC]]
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[[Category: Proteasa, G.]]
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[[Category: Proteasa G]]
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[[Category: Terlecky, S R.]]
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[[Category: Terlecky SR]]
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[[Category: Vickrey, J F.]]
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[[Category: Vickrey JF]]
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[[Category: Wawrzak, Z.]]
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[[Category: Wawrzak Z]]
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[[Category: Winters, M A.]]
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[[Category: Winters MA]]
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[[Category: Aid]]
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[[Category: Aspartyl protease]]
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[[Category: Hiv protease]]
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[[Category: Hydrolase]]
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[[Category: Lopinavir]]
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[[Category: Multi-drug resistance]]
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[[Category: Polyprotein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:29:27 2008''
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Current revision

Crystal structures of a Multidrug-Resistant HIV-1 Protease Reveal an Expanded Active Site Cavity

PDB ID 1rv7

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