2f3z

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{{Seed}}
 
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[[Image:2f3z.png|left|200px]]
 
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==Calmodulin/IQ-AA domain complex==
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The line below this paragraph, containing "STRUCTURE_2f3z", creates the "Structure Box" on the page.
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<StructureSection load='2f3z' size='340' side='right'caption='[[2f3z]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2f3z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F3Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F3Z FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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{{STRUCTURE_2f3z| PDB=2f3z | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f3z OCA], [https://pdbe.org/2f3z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f3z RCSB], [https://www.ebi.ac.uk/pdbsum/2f3z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f3z ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of CPVT4. The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of LQT14.
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== Function ==
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[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).<ref>PMID:16760425</ref> <ref>PMID:23893133</ref> <ref>PMID:26969752</ref> <ref>PMID:27165696</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f3/2f3z_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f3z ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Ca2+-dependent inactivation (CDI) and facilitation (CDF) of the Ca(v)1.2 Ca2+ channel require calmodulin binding to a putative IQ motif in the carboxy-terminal tail of the pore-forming subunit. We present the 1.45 A crystal structure of Ca2+-calmodulin bound to a 21 residue peptide corresponding to the IQ domain of Ca(v)1.2. This structure shows that parallel binding of calmodulin to the IQ domain is governed by hydrophobic interactions. Mutations of residues I1672 and Q1673 in the peptide to alanines, which abolish CDI but not CDF in the channel, do not greatly alter the structure. Both lobes of Ca2+-saturated CaM bind to the IQ peptide but isoleucine 1672, thought to form an intramolecular interaction that drives CDI, is buried. These findings suggest that this structure could represent the conformation that calmodulin assumes in CDF.
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===Calmodulin/IQ-AA domain complex===
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Structure of calmodulin bound to the hydrophobic IQ domain of the cardiac Ca(v)1.2 calcium channel.,Fallon JL, Halling DB, Hamilton SL, Quiocho FA Structure. 2005 Dec;13(12):1881-6. PMID:16338416<ref>PMID:16338416</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2f3z" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_16338416}}, adds the Publication Abstract to the page
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*[[Calmodulin 3D structures|Calmodulin 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 16338416 is the PubMed ID number.
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*[[Ion channels 3D structures|Ion channels 3D structures]]
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== References ==
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{{ABSTRACT_PUBMED_16338416}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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2F3Z is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F3Z OCA].
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==Reference==
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Structure of calmodulin bound to the hydrophobic IQ domain of the cardiac Ca(v)1.2 calcium channel., Fallon JL, Halling DB, Hamilton SL, Quiocho FA, Structure. 2005 Dec;13(12):1881-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16338416 16338416]
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Target enzyme recognition by calmodulin: 2.4 A structure of a calmodulin-peptide complex., Meador WE, Means AR, Quiocho FA, Science. 1992 Aug 28;257(5074):1251-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1519061 1519061]
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A closed compact structure of native Ca(2+)-calmodulin., Fallon JL, Quiocho FA, Structure. 2003 Oct;11(10):1303-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14527397 14527397]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Fallon, J L.]]
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[[Category: Fallon JL]]
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[[Category: Quiocho, F A.]]
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[[Category: Quiocho FA]]
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[[Category: Calcium channnel]]
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[[Category: Calmodulin]]
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[[Category: Calmodulin complex]]
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[[Category: Cav1 2]]
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[[Category: Iq domain]]
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[[Category: Iq-aa mutant domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:37:16 2008''
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Current revision

Calmodulin/IQ-AA domain complex

PDB ID 2f3z

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