1s8a

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{{Seed}}
 
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[[Image:1s8a.png|left|200px]]
 
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==H98Q Mutant of Methylglyoxal Synthase from E. coli complexed with Phosphoglycolic Acid==
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The line below this paragraph, containing "STRUCTURE_1s8a", creates the "Structure Box" on the page.
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<StructureSection load='1s8a' size='340' side='right'caption='[[1s8a]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1s8a]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S8A FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGA:2-PHOSPHOGLYCOLIC+ACID'>PGA</scene></td></tr>
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{{STRUCTURE_1s8a| PDB=1s8a | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s8a OCA], [https://pdbe.org/1s8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s8a RCSB], [https://www.ebi.ac.uk/pdbsum/1s8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s8a ProSAT]</span></td></tr>
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</table>
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===H98Q Mutant of Methylglyoxal Synthase from E. coli complexed with Phosphoglycolic Acid===
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== Function ==
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[https://www.uniprot.org/uniprot/MGSA_ECOLI MGSA_ECOLI]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_15049687}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 15049687 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s8/1s8a_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_15049687}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1S8A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S8A OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s8a ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Mutagenic studies on histidine 98 of methylglyoxal synthase: effects on mechanism and conformational change., Marks GT, Susler M, Harrison DH, Biochemistry. 2004 Apr 6;43(13):3802-13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15049687 15049687]
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Methylglyoxal synthase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Harrison DH]]
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[[Category: Harrison, D H.]]
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[[Category: Marks GT]]
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[[Category: Marks, G T.]]
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[[Category: Susler M]]
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[[Category: Susler, M.]]
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[[Category: Glycolytic bypass]]
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[[Category: Lyase]]
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[[Category: Methylglyoxal]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:42:56 2008''
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Current revision

H98Q Mutant of Methylglyoxal Synthase from E. coli complexed with Phosphoglycolic Acid

PDB ID 1s8a

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