1ozn

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{{Seed}}
 
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[[Image:1ozn.png|left|200px]]
 
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==1.5A Crystal Structure of the Nogo Receptor Ligand Binding Domain Reveals a Convergent Recognition Scaffold Mediating Inhibition of Myelination==
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The line below this paragraph, containing "STRUCTURE_1ozn", creates the "Structure Box" on the page.
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<StructureSection load='1ozn' size='340' side='right'caption='[[1ozn]], [[Resolution|resolution]] 1.52&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ozn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OZN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OZN FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.52&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
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{{STRUCTURE_1ozn| PDB=1ozn | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ozn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ozn OCA], [https://pdbe.org/1ozn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ozn RCSB], [https://www.ebi.ac.uk/pdbsum/1ozn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ozn ProSAT]</span></td></tr>
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</table>
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===1.5A Crystal Structure of the Nogo Receptor Ligand Binding Domain Reveals a Convergent Recognition Scaffold Mediating Inhibition of Myelination===
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== Function ==
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[https://www.uniprot.org/uniprot/RTN4R_HUMAN RTN4R_HUMAN] Receptor for RTN4, OMG and MAG. Mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. Acts in conjunction with RTN4 and LIGO1 in regulating neuronal precursor cell motility during cortical development (By similarity).<ref>PMID:12037567</ref> <ref>PMID:14966521</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_12718853}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 12718853 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oz/1ozn_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_12718853}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1OZN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OZN OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ozn ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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Structure of the Nogo receptor ectodomain: a recognition module implicated in myelin inhibition., He XL, Bazan JF, McDermott G, Park JB, Wang K, Tessier-Lavigne M, He Z, Garcia KC, Neuron. 2003 Apr 24;38(2):177-85. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12718853 12718853]
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bazan, J F.]]
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[[Category: Bazan JF]]
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[[Category: Garcia, K C.]]
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[[Category: Garcia KC]]
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[[Category: He, X.]]
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[[Category: He X]]
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[[Category: He, Z.]]
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[[Category: He Z]]
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[[Category: McDermott, G.]]
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[[Category: McDermott G]]
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[[Category: Park, J B.]]
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[[Category: Park JB]]
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[[Category: Crystal structure]]
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[[Category: Ligand binding]]
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[[Category: Mad]]
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[[Category: Mag]]
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[[Category: Myelination inhibition]]
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[[Category: Neuronal regeneration]]
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[[Category: Nogo receptor]]
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[[Category: Nogo-66]]
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[[Category: Omgp]]
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[[Category: P75]]
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[[Category: Signal transduction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:44:21 2008''
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Current revision

1.5A Crystal Structure of the Nogo Receptor Ligand Binding Domain Reveals a Convergent Recognition Scaffold Mediating Inhibition of Myelination

PDB ID 1ozn

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