2aze

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{{Seed}}
 
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[[Image:2aze.png|left|200px]]
 
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==Structure of the Rb C-terminal domain bound to an E2F1-DP1 heterodimer==
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The line below this paragraph, containing "STRUCTURE_2aze", creates the "Structure Box" on the page.
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<StructureSection load='2aze' size='340' side='right'caption='[[2aze]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2aze]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AZE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AZE FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aze OCA], [https://pdbe.org/2aze PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aze RCSB], [https://www.ebi.ac.uk/pdbsum/2aze PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aze ProSAT]</span></td></tr>
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{{STRUCTURE_2aze| PDB=2aze | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TFDP1_HUMAN TFDP1_HUMAN] Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812).<ref>PMID:20176812</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/az/2aze_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2aze ConSurf].
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<div style="clear:both"></div>
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===Structure of the Rb C-terminal domain bound to an E2F1-DP1 heterodimer===
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==See Also==
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*[[Retinoblastoma protein|Retinoblastoma protein]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_16360038}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 16360038 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_16360038}}
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==Disease==
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Known disease associated with this structure: Bladder cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=180200 180200]], Osteosarcoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=180200 180200]], Pinealoma with bilateral retinoblastoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=180200 180200]], Retinoblastoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=180200 180200]]
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==About this Structure==
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2AZE is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AZE OCA].
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==Reference==
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Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release., Rubin SM, Gall AL, Zheng N, Pavletich NP, Cell. 2005 Dec 16;123(6):1093-106. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16360038 16360038]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Gall, A L.]]
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[[Category: Gall AL]]
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[[Category: Pavletich, N P.]]
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[[Category: Pavletich NP]]
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[[Category: Rubin, S M.]]
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[[Category: Rubin SM]]
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[[Category: Zheng, N.]]
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[[Category: Zheng N]]
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[[Category: Beta sandwich]]
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[[Category: Coiled coil]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:50:56 2008''
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Current revision

Structure of the Rb C-terminal domain bound to an E2F1-DP1 heterodimer

PDB ID 2aze

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