1tf3

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{{Seed}}
 
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[[Image:1tf3.png|left|200px]]
 
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==TFIIIA FINGER 1-3 BOUND TO DNA, NMR, 22 STRUCTURES==
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The line below this paragraph, containing "STRUCTURE_1tf3", creates the "Structure Box" on the page.
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<StructureSection load='1tf3' size='340' side='right'caption='[[1tf3]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1tf3]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TF3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TF3 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1tf3| PDB=1tf3 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tf3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tf3 OCA], [https://pdbe.org/1tf3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tf3 RCSB], [https://www.ebi.ac.uk/pdbsum/1tf3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tf3 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TF3A_XENLA TF3A_XENLA] Acts as both a positive transcription factor for 5S RNA genes and a specific RNA binding protein that complexes with 5S RNA in oocytes to form the 7S ribonucleoprotein storage particle. May play an essential role in the developmental change in 5S RNA gene expression. Interacts with the internal control region (ICR) of approximately 50 bases within the 5S RNA genes, is required for correct transcription of these genes by RNA polymerase III. Also binds the transcribed 5S RNA's.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tf/1tf3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tf3 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The three N-terminal zinc fingers of transcription factor IIIA bind in the DNA major groove. Substantial packing interfaces are formed between adjacent fingers, the linkers lose their intrinsic flexibility upon DNA binding, and several lysine side chains implicated in DNA recognition are dynamically disordered.
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===TFIIIA FINGER 1-3 BOUND TO DNA, NMR, 22 STRUCTURES===
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Domain packing and dynamics in the DNA complex of the N-terminal zinc fingers of TFIIIA.,Foster MP, Wuttke DS, Radhakrishnan I, Case DA, Gottesfeld JM, Wright PE Nat Struct Biol. 1997 Aug;4(8):605-8. PMID:9253405<ref>PMID:9253405</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_9253405}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1tf3" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 9253405 is the PubMed ID number.
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== References ==
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-->
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<references/>
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{{ABSTRACT_PUBMED_9253405}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1TF3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TF3 OCA].
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==Reference==
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Domain packing and dynamics in the DNA complex of the N-terminal zinc fingers of TFIIIA., Foster MP, Wuttke DS, Radhakrishnan I, Case DA, Gottesfeld JM, Wright PE, Nat Struct Biol. 1997 Aug;4(8):605-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9253405 9253405]
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[[Category: Single protein]]
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[[Category: Xenopus laevis]]
[[Category: Xenopus laevis]]
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[[Category: Case, D A.]]
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[[Category: Case DA]]
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[[Category: Foster, M P.]]
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[[Category: Foster MP]]
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[[Category: Gottesfeld, J M.]]
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[[Category: Gottesfeld JM]]
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[[Category: Radhakrishnan, I.]]
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[[Category: Radhakrishnan I]]
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[[Category: Wright, P E.]]
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[[Category: Wright PE]]
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[[Category: Wuttke, D S.]]
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[[Category: Wuttke DS]]
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[[Category: 5s rna gene]]
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[[Category: Dna]]
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[[Category: Dna binding protein]]
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[[Category: Nmr]]
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[[Category: Protein]]
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[[Category: Tfiiia]]
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[[Category: Transcription factor]]
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[[Category: Zinc finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:15:32 2008''
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Current revision

TFIIIA FINGER 1-3 BOUND TO DNA, NMR, 22 STRUCTURES

PDB ID 1tf3

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