2g0u

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{{Seed}}
 
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[[Image:2g0u.gif|left|200px]]
 
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==Solution Structure of Monomeric BsaL, the Type III Secretion Needle Protein of Burkholderia pseudomallei==
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The line below this paragraph, containing "STRUCTURE_2g0u", creates the "Structure Box" on the page.
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<StructureSection load='2g0u' size='340' side='right'caption='[[2g0u]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2g0u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G0U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G0U FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g0u OCA], [https://pdbe.org/2g0u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g0u RCSB], [https://www.ebi.ac.uk/pdbsum/2g0u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g0u ProSAT]</span></td></tr>
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{{STRUCTURE_2g0u| PDB=2g0u | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q63K18_BURPS Q63K18_BURPS]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g0/2g0u_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g0u ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Many gram-negative bacteria that are important human pathogens possess type III secretion systems as part of their required virulence factor repertoire. During the establishment of infection, these pathogens coordinately assemble greater than 20 different proteins into a macromolecular structure that spans the bacterial inner and outer membranes and, in many respects, resembles and functions like a syringe. This type III secretion apparatus (TTSA) is used to inject proteins into a host cell's membrane and cytoplasm to subvert normal cellular processes. The external portion of the TTSA is a needle that is composed of a single type of protein that is polymerized in a helical fashion to form an elongated tube with a central channel of 2-3 nm in diameter. TTSA needle proteins from a variety of bacterial pathogens share sequence conservation; however, no atomic structure for any TTSA needle protein is yet available. Here, we report the structure of a TTSA needle protein called BsaL from Burkholderia pseudomallei determined by nuclear magnetic resonance (NMR) spectroscopy. The central part of the protein assumes a helix-turn-helix core domain with two well-defined alpha-helices that are joined by an ordered, four-residue linker. This forms a two-helix bundle that is stabilized by interhelix hydrophobic contacts. Residues that flank this presumably exposed core region are not completely disordered, but adopt a partial helical conformation. The atomic structure of BsaL and its sequence homology with other TTSA needle proteins suggest potentially unique structural dynamics that could be linked with a universal mechanism for control of type III secretion in diverse gram-negative bacterial pathogens.
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===Solution Structure of Monomeric BsaL, the Type III Secretion Needle Protein of Burkholderia pseudomallei===
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Solution structure of monomeric BsaL, the type III secretion needle protein of Burkholderia pseudomallei.,Zhang L, Wang Y, Picking WL, Picking WD, De Guzman RN J Mol Biol. 2006 Jun 2;359(2):322-30. Epub 2006 Mar 30. PMID:16631790<ref>PMID:16631790</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2g0u" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16631790 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16631790}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2G0U is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G0U OCA].
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==Reference==
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Solution structure of monomeric BsaL, the type III secretion needle protein of Burkholderia pseudomallei., Zhang L, Wang Y, Picking WL, Picking WD, De Guzman RN, J Mol Biol. 2006 Jun 2;359(2):322-30. Epub 2006 Mar 30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16631790 16631790]
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[[Category: Burkholderia pseudomallei]]
[[Category: Burkholderia pseudomallei]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Guzman, R N.De.]]
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[[Category: De Guzman RN]]
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[[Category: Picking, W D.]]
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[[Category: Picking WD]]
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[[Category: Picking, W L.]]
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[[Category: Picking WL]]
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[[Category: Wang, Y.]]
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[[Category: Wang Y]]
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[[Category: Zhang, L.]]
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[[Category: Zhang L]]
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[[Category: Helix-turn-helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:45:33 2008''
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Current revision

Solution Structure of Monomeric BsaL, the Type III Secretion Needle Protein of Burkholderia pseudomallei

PDB ID 2g0u

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