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1r0w

From Proteopedia

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{{Seed}}
 
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[[Image:1r0w.png|left|200px]]
 
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==Cystic fibrosis transmembrane conductance regulator (CFTR) nucleotide-binding domain one (NBD1) apo==
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The line below this paragraph, containing "STRUCTURE_1r0w", creates the "Structure Box" on the page.
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<StructureSection load='1r0w' size='340' side='right'caption='[[1r0w]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1r0w]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R0W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R0W FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene></td></tr>
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{{STRUCTURE_1r0w| PDB=1r0w | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r0w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r0w OCA], [https://pdbe.org/1r0w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r0w RCSB], [https://www.ebi.ac.uk/pdbsum/1r0w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r0w ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CFTR_MOUSE CFTR_MOUSE] Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1 (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r0/1r0w_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r0w ConSurf].
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<div style="clear:both"></div>
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===Cystic fibrosis transmembrane conductance regulator (CFTR) nucleotide-binding domain one (NBD1) apo===
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==See Also==
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*[[ABC transporter 3D structures|ABC transporter 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_14685259}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 14685259 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14685259}}
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==About this Structure==
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1R0W is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R0W OCA].
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==Reference==
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Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator., Lewis HA, Buchanan SG, Burley SK, Conners K, Dickey M, Dorwart M, Fowler R, Gao X, Guggino WB, Hendrickson WA, Hunt JF, Kearins MC, Lorimer D, Maloney PC, Post KW, Rajashankar KR, Rutter ME, Sauder JM, Shriver S, Thibodeau PH, Thomas PJ, Zhang M, Zhao X, Emtage S, EMBO J. 2004 Jan 28;23(2):282-93. Epub 2003 Dec 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14685259 14685259]
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Buchanan SG]]
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[[Category: Buchanan, S G.]]
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[[Category: Burley SK]]
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[[Category: Burley, S K.]]
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[[Category: Conners K]]
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[[Category: Conners, K.]]
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[[Category: Dickey M]]
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[[Category: Dickey, M.]]
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[[Category: Dorwart M]]
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[[Category: Dorwart, M.]]
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[[Category: Fowler R]]
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[[Category: Fowler, R.]]
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[[Category: Gao X]]
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[[Category: Gao, X.]]
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[[Category: Guggino WB]]
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[[Category: Guggino, W B.]]
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[[Category: Hendrickson WA]]
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[[Category: Hendrickson, W A.]]
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[[Category: Lewis HA]]
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[[Category: Lewis, H A.]]
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[[Category: Abc transporter nucleotide binding domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:46:32 2008''
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Current revision

Cystic fibrosis transmembrane conductance regulator (CFTR) nucleotide-binding domain one (NBD1) apo

PDB ID 1r0w

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