1pl8

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{{Seed}}
 
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[[Image:1pl8.png|left|200px]]
 
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==human SDH/NAD+ complex==
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The line below this paragraph, containing "STRUCTURE_1pl8", creates the "Structure Box" on the page.
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<StructureSection load='1pl8' size='340' side='right'caption='[[1pl8]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1pl8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PL8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PL8 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1pl8| PDB=1pl8 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pl8 OCA], [https://pdbe.org/1pl8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pl8 RCSB], [https://www.ebi.ac.uk/pdbsum/1pl8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pl8 ProSAT]</span></td></tr>
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</table>
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===human SDH/NAD+ complex===
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== Function ==
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[https://www.uniprot.org/uniprot/DHSO_HUMAN DHSO_HUMAN] Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm (By similarity).<ref>PMID:16278369</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 12962626 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pl/1pl8_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_12962626}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1PL8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PL8 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pl8 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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X-ray crystallographic and kinetic studies of human sorbitol dehydrogenase., Pauly TA, Ekstrom JL, Beebe DA, Chrunyk B, Cunningham D, Griffor M, Kamath A, Lee SE, Madura R, Mcguire D, Subashi T, Wasilko D, Watts P, Mylari BL, Oates PJ, Adams PD, Rath VL, Structure. 2003 Sep;11(9):1071-85. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12962626 12962626]
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: L-iditol 2-dehydrogenase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Adams PD]]
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[[Category: Adams, P D.]]
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[[Category: Beebe DA]]
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[[Category: Beebe, D A.]]
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[[Category: Chrunyk B]]
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[[Category: Chrunyk, B.]]
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[[Category: Cunningham D]]
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[[Category: Cunningham, D.]]
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[[Category: Ekstrom JL]]
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[[Category: Ekstrom, J L.]]
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[[Category: Griffor M]]
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[[Category: Griffor, M.]]
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[[Category: Kamath A]]
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[[Category: Kamath, A.]]
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[[Category: Lee SE]]
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[[Category: Lee, S E.]]
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[[Category: Madura R]]
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[[Category: Madura, R.]]
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[[Category: Mcguire D]]
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[[Category: Mcguire, D.]]
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[[Category: Mylari BL]]
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[[Category: Mylari, B L.]]
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[[Category: Oates PJ]]
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[[Category: Oates, P J.]]
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[[Category: Pauly TA]]
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[[Category: Pauly, T A.]]
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[[Category: Rath VL]]
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[[Category: Rath, V L.]]
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[[Category: Subashi T]]
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[[Category: Subashi, T.]]
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[[Category: Wasilko D]]
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[[Category: Wasilko, D.]]
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[[Category: Watts P]]
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[[Category: Watts, P.]]
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[[Category: Human sorbitol dehydrogenase]]
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[[Category: Nad]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:48:08 2008''
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Current revision

human SDH/NAD+ complex

PDB ID 1pl8

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