2vcg

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{{Seed}}
 
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[[Image:2vcg.png|left|200px]]
 
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==Crystal structure of a HDAC-like protein HDAH from Bordetella sp. with the bound inhibitor ST-17==
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The line below this paragraph, containing "STRUCTURE_2vcg", creates the "Structure Box" on the page.
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<StructureSection load='2vcg' size='340' side='right'caption='[[2vcg]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2vcg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Alcaligenes_sp. Alcaligenes sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VCG FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=S17:METHYL+4-BROMO-N-[8-(HYDROXYAMINO)-8-OXOOCTANOYL]-L-PHENYLALANINATE'>S17</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_2vcg| PDB=2vcg | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vcg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vcg OCA], [https://pdbe.org/2vcg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vcg RCSB], [https://www.ebi.ac.uk/pdbsum/2vcg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vcg ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HDAH_ALCSD HDAH_ALCSD]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vc/2vcg_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vcg ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We synthesized biarylalanine-containing hydroxamic acids and tested them on immunoprecipitated HDAC1 and HDAC6 and show a subtype selectivity for HDAC6 that was confirmed in cells by Western blot (tubulin vs histones). We obtained an X-ray structure with a HDAC6-selective inhibitor with the bacterial deacetylase HDAH. Docking studies were carried out using HDAC1 and HDAC6 protein models. Antiproliferative activity was shown on cancer cells for selected compounds.
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===CRYSTAL STRUCTURE OF A HDAC-LIKE PROTEIN HDAH FROM BORDETELLA SP. WITH THE BOUND INHIBITOR ST-17===
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Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs).,Schafer S, Saunders L, Eliseeva E, Velena A, Jung M, Schwienhorst A, Strasser A, Dickmanns A, Ficner R, Schlimme S, Sippl W, Verdin E, Jung M Bioorg Med Chem. 2008 Feb 15;16(4):2011-33. Epub 2007 Nov 4. PMID:18054239<ref>PMID:18054239</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2vcg" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_18054239}}, adds the Publication Abstract to the page
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*[[Histone deacetylase 3D structures|Histone deacetylase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 18054239 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18054239}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Alcaligenes sp]]
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2VCG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Alcaligenes_sp. Alcaligenes sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCG OCA].
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[[Category: Large Structures]]
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[[Category: Dickmanns A]]
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==Reference==
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[[Category: Ficner R]]
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Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs)., Schafer S, Saunders L, Eliseeva E, Velena A, Jung M, Schwienhorst A, Strasser A, Dickmanns A, Ficner R, Schlimme S, Sippl W, Verdin E, Jung M, Bioorg Med Chem. 2008 Feb 15;16(4):2011-33. Epub 2007 Nov 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18054239 18054239]
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[[Category: Strasser A]]
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[[Category: Alcaligenes sp.]]
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[[Category: Single protein]]
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[[Category: Dickmanns, A.]]
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[[Category: Ficner, R.]]
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[[Category: Strasser, A.]]
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[[Category: Hdac-like amidohydrolase]]
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[[Category: Hdah]]
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[[Category: Histone deacetylase-like amidohydrolase]]
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[[Category: Hydrolase]]
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[[Category: Inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:48:24 2008''
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Current revision

Crystal structure of a HDAC-like protein HDAH from Bordetella sp. with the bound inhibitor ST-17

PDB ID 2vcg

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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