2jo7

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{{Seed}}
 
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[[Image:2jo7.png|left|200px]]
 
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==Solution structure of the adhesion protein Bd37 from Babesia divergens==
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The line below this paragraph, containing "STRUCTURE_2jo7", creates the "Structure Box" on the page.
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<StructureSection load='2jo7' size='340' side='right'caption='[[2jo7]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2jo7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Babesia_divergens Babesia divergens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JO7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JO7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jo7 OCA], [https://pdbe.org/2jo7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jo7 RCSB], [https://www.ebi.ac.uk/pdbsum/2jo7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jo7 ProSAT]</span></td></tr>
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{{STRUCTURE_2jo7| PDB=2jo7 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8T117_BABDI Q8T117_BABDI]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Babesia divergens is the Apicomplexa agent of the bovine babesiosis in Europe: this infection leads to growth and lactation decrease, so that economical losses due to this parasite are sufficient to require the development of a vaccine. The major surface antigen of B. divergens has been described as a 37 kDa protein glycosyl phosphatidyl inositol (GPI)-anchored at the surface of the merozoite. The immuno-prophylactic potential of Bd37 has been demonstrated, and we present here the high-resolution solution structure of the 27 kDa structured core of Bd37 (Delta-Bd37) using NMR spectroscopy. A model for the whole protein has been obtained using additional small angle X-ray scattering (SAXS) data. The knowledge of the 3D structure of Bd37 allowed the precise epitope mapping of antibodies on its surface. Interestingly, the geometry of Delta-Bd37 reveals an intriguing similarity with the exocyst subunit Exo84p C-terminal region, an eukaryotic protein that has a direct implication in vesicle trafficking. This strongly suggests that Apicomplexa have developed in parallel molecular machines similar in structure and function to the ones used for endo- and exocytosis in eukaryotic cells.
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===Solution structure of the adhesion protein Bd37 from Babesia divergens===
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The solution structure of the adhesion protein Bd37 from Babesia divergens reveals structural homology with eukaryotic proteins involved in membrane trafficking.,Delbecq S, Auguin D, Yang YS, Lohr F, Arold S, Schetters T, Precigout E, Gorenflot A, Roumestand C J Mol Biol. 2008 Jan 11;375(2):409-24. Epub 2007 Aug 21. PMID:18035372<ref>PMID:18035372</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_18035372}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2jo7" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 18035372 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18035372}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2JO7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Babesia_divergens Babesia divergens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JO7 OCA].
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==Reference==
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The solution structure of the adhesion protein Bd37 from Babesia divergens reveals structural homology with eukaryotic proteins involved in membrane trafficking., Delbecq S, Auguin D, Yang YS, Lohr F, Arold S, Schetters T, Precigout E, Gorenflot A, Roumestand C, J Mol Biol. 2008 Jan 11;375(2):409-24. Epub 2007 Aug 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18035372 18035372]
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[[Category: Babesia divergens]]
[[Category: Babesia divergens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arold, S.]]
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[[Category: Arold S]]
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[[Category: Auguin, D.]]
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[[Category: Auguin D]]
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[[Category: Delbecq, S.]]
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[[Category: Delbecq S]]
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[[Category: Gorenflot, A.]]
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[[Category: Gorenflot A]]
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[[Category: Lohr, F.]]
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[[Category: Lohr F]]
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[[Category: Precigout, E.]]
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[[Category: Precigout E]]
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[[Category: Roumestand, C.]]
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[[Category: Roumestand C]]
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[[Category: Schetters, T.]]
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[[Category: Schetters T]]
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[[Category: Yang, Y.]]
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[[Category: Yang Y]]
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[[Category: Babesia divergen]]
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[[Category: Gpi-anchored protein]]
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[[Category: Recombinant vaccine]]
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[[Category: Surface active protein]]
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[[Category: Surface antigen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:48:47 2008''
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Current revision

Solution structure of the adhesion protein Bd37 from Babesia divergens

PDB ID 2jo7

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