1nl3

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(New page: 200px<br /><applet load="1nl3" size="450" color="white" frame="true" align="right" spinBox="true" caption="1nl3, resolution 2.800&Aring;" /> '''CRYSTAL STRUCTURE O...)
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[[Image:1nl3.gif|left|200px]]<br /><applet load="1nl3" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1nl3, resolution 2.800&Aring;" />
 
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'''CRYSTAL STRUCTURE OF THE SECA PROTEIN TRANSLOCATION ATPASE FROM MYCOBACTERIUM TUBERCULOSIS in APO FORM'''<br />
 
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==Overview==
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==CRYSTAL STRUCTURE OF THE SECA PROTEIN TRANSLOCATION ATPASE FROM MYCOBACTERIUM TUBERCULOSIS in APO FORM==
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In bacteria, the majority of exported proteins are translocated by the Sec, system, which recognizes the signal sequence of a preprotein and uses ATP, and the proton motive force to mediate protein translocation across the, cytoplasmic membrane. SecA is an essential protein component of this, system, containing the molecular motor that facilitates translocation., Here we report the three-dimensional structure of the SecA protein of, Mycobacterium tuberculosis. Each subunit of the homodimer contains a, "motor" domain and a translocation domain. The structure predicts that, SecA can interact with the SecYEG pore and function as a molecular ratchet, that uses ATP hydrolysis for physical movement of the preprotein., Knowledge of this structure provides a framework for further elucidation, of the translocation process.
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<StructureSection load='1nl3' size='340' side='right'caption='[[1nl3]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1nl3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NL3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NL3 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nl3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nl3 OCA], [https://pdbe.org/1nl3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nl3 RCSB], [https://www.ebi.ac.uk/pdbsum/1nl3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nl3 ProSAT], [https://www.topsan.org/Proteins/TBSGC/1nl3 TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SECA1_MYCTU SECA1_MYCTU] Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of precursor proteins, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nl/1nl3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nl3 ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1NL3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1NL3 OCA].
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*[[Preprotein translocase 3D structures|Preprotein translocase 3D structures]]
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*[[SecA|SecA]]
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==Reference==
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__TOC__
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Crystal structure of Mycobacterium tuberculosis SecA, a preprotein translocating ATPase., Sharma V, Arockiasamy A, Ronning DR, Savva CG, Holzenburg A, Braunstein M, Jacobs WR Jr, Sacchettini JC, Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2243-8. Epub 2003 Feb 26. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12606717 12606717]
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: Single protein]]
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[[Category: Arockiasamy A]]
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[[Category: Arockiasamy, A.]]
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[[Category: Braunstein M]]
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[[Category: Braunstein, M.]]
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[[Category: Holzenburg A]]
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[[Category: Holzenburg, A.]]
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[[Category: Jacobs Jr WR]]
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[[Category: Jr., W.R.Jacobs.]]
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[[Category: Ronning DR]]
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[[Category: Ronning, D.R.]]
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[[Category: Sacchettini JC]]
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[[Category: Sacchettini, J.C.]]
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[[Category: Savva CG]]
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[[Category: Savva, C.G.]]
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[[Category: Sharma V]]
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[[Category: Sharma, V.]]
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[[Category: TBSGC, TB.Structural.Genomics.Consortium.]]
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[[Category: atpase]]
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[[Category: helicase-like motor domain]]
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[[Category: preprotein translocation]]
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[[Category: protein structure initiative]]
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[[Category: psi]]
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[[Category: structural genomics]]
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[[Category: tb structural genomics consortium]]
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[[Category: tbsgc]]
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[[Category: transmembrane transport]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 22:21:24 2007''
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Current revision

CRYSTAL STRUCTURE OF THE SECA PROTEIN TRANSLOCATION ATPASE FROM MYCOBACTERIUM TUBERCULOSIS in APO FORM

PDB ID 1nl3

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